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PubMed:2071611 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-165 Sentence denotes A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization.
T1 0-165 Sentence denotes A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization.
TextSentencer_T2 166-301 Sentence denotes A congenitally abnormal fibrinogen (Vlissingen) was isolated from the blood of a young woman suffering from massive pulmonary embolism.
T2 166-301 Sentence denotes A congenitally abnormal fibrinogen (Vlissingen) was isolated from the blood of a young woman suffering from massive pulmonary embolism.
TextSentencer_T3 302-390 Sentence denotes Fibrinogen Vlissingen showed an abnormal clotting time with both thrombin and Reptilase.
T3 302-390 Sentence denotes Fibrinogen Vlissingen showed an abnormal clotting time with both thrombin and Reptilase.
TextSentencer_T4 391-544 Sentence denotes The release of the fibrino-peptides A and B by thrombin was normal, but fibrin polymerization was impaired both in the presence and absence of Ca2+ ions.
T4 391-544 Sentence denotes The release of the fibrino-peptides A and B by thrombin was normal, but fibrin polymerization was impaired both in the presence and absence of Ca2+ ions.
TextSentencer_T5 545-780 Sentence denotes On sodium dodecyl sulfate-polyacrylamide gel electrophoresis performed according to Laemmli the gamma-chain of fibrinogen Vlissingen showed two bands, one normal and one having an apparently lower molecular mass of about 1,500 daltons.
T5 545-780 Sentence denotes On sodium dodecyl sulfate-polyacrylamide gel electrophoresis performed according to Laemmli the gamma-chain of fibrinogen Vlissingen showed two bands, one normal and one having an apparently lower molecular mass of about 1,500 daltons.
TextSentencer_T6 781-980 Sentence denotes The previously described protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain of normal fibrinogen was only partially detectable in fibrinogen Vlissingen.
T6 781-980 Sentence denotes The previously described protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain of normal fibrinogen was only partially detectable in fibrinogen Vlissingen.
TextSentencer_T7 981-1032 Sentence denotes In addition the binding of Ca2+ ions was decreased.
T7 981-1032 Sentence denotes In addition the binding of Ca2+ ions was decreased.
TextSentencer_T8 1033-1156 Sentence denotes Fibrinogen Vlissingen bound 2.4 Ca2+ ions per fibrinogen molecule at pH 7.4, whereas normal fibrinogen bound 3.1 Ca2+ ions.
T8 1033-1156 Sentence denotes Fibrinogen Vlissingen bound 2.4 Ca2+ ions per fibrinogen molecule at pH 7.4, whereas normal fibrinogen bound 3.1 Ca2+ ions.
TextSentencer_T9 1157-1374 Sentence denotes At pH 5.8 fibrinogen Vlissingen bound 1.1 Ca2+ ions, whereas normal fibrinogen bound 2.0 Ca2+ ions per molecule fibrinogen in the D-domains, again indicating a structural change in the carboxyl terminus of fibrinogen.
T9 1157-1374 Sentence denotes At pH 5.8 fibrinogen Vlissingen bound 1.1 Ca2+ ions, whereas normal fibrinogen bound 2.0 Ca2+ ions per molecule fibrinogen in the D-domains, again indicating a structural change in the carboxyl terminus of fibrinogen.
TextSentencer_T10 1375-1490 Sentence denotes The structural defect was determined by sequence analysis of DNA amplified by use of the polymerase chain reaction.
T10 1375-1490 Sentence denotes The structural defect was determined by sequence analysis of DNA amplified by use of the polymerase chain reaction.
TextSentencer_T11 1491-1615 Sentence denotes Exons VIII, IX, and X of the gamma-chain gene were amplified and the DNA sequence of the amplified fragments was determined.
T11 1491-1615 Sentence denotes Exons VIII, IX, and X of the gamma-chain gene were amplified and the DNA sequence of the amplified fragments was determined.
TextSentencer_T12 1616-1758 Sentence denotes A 6-base deletion was found in 50% of the fragments corresponding to exon VIII, indicating that the patient was heterozygous for the mutation.
T12 1616-1758 Sentence denotes A 6-base deletion was found in 50% of the fragments corresponding to exon VIII, indicating that the patient was heterozygous for the mutation.
TextSentencer_T13 1759-1852 Sentence denotes This deletion codes for amino acids Asn-319 and Asp-320 in the normal fibrinogen gamma-chain.
T13 1759-1852 Sentence denotes This deletion codes for amino acids Asn-319 and Asp-320 in the normal fibrinogen gamma-chain.
TextSentencer_T14 1853-2158 Sentence denotes The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen.
T14 1853-2158 Sentence denotes The data indicate that Asn-319 and Asp-320 are crucial for maintaining the integrity of the carboxyl-terminal polymerization sites, the protective effect of Ca2+ ions on plasmin degradation of the carboxyl terminus of the gamma-chain, and the calcium binding domain at the carboxyl terminus of fibrinogen.