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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-183 Sentence denotes Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.
T1 0-183 Sentence denotes Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.
TextSentencer_T2 184-192 Sentence denotes PURPOSE:
T2 184-192 Sentence denotes PURPOSE:
TextSentencer_T3 193-384 Sentence denotes Bortezomib induces unfolded protein response (UPR) and endoplasmic reticulum stress, as well as exhibits clinical activity in patients with relapsed and refractory mantle cell lymphoma (MCL).
T3 193-384 Sentence denotes Bortezomib induces unfolded protein response (UPR) and endoplasmic reticulum stress, as well as exhibits clinical activity in patients with relapsed and refractory mantle cell lymphoma (MCL).
TextSentencer_T4 385-606 Sentence denotes Here, we determined the molecular basis of the improved in vitro and in vivo activity of the combination of the pan-histone deacetylase inhibitor panobinostat and bortezomib against human, cultured, and primary MCL cells.
T4 385-606 Sentence denotes Here, we determined the molecular basis of the improved in vitro and in vivo activity of the combination of the pan-histone deacetylase inhibitor panobinostat and bortezomib against human, cultured, and primary MCL cells.
TextSentencer_T5 607-627 Sentence denotes EXPERIMENTAL DESIGN:
T5 607-627 Sentence denotes EXPERIMENTAL DESIGN:
TextSentencer_T6 628-861 Sentence denotes Immunoblot analyses, reverse transcription-PCR, and immunofluorescent and electron microscopy were used to determine the effects of panobinostat on bortezomib-induced aggresome formation and endoplasmic reticulum stress in MCL cells.
T6 628-861 Sentence denotes Immunoblot analyses, reverse transcription-PCR, and immunofluorescent and electron microscopy were used to determine the effects of panobinostat on bortezomib-induced aggresome formation and endoplasmic reticulum stress in MCL cells.
TextSentencer_T7 862-870 Sentence denotes RESULTS:
T7 862-870 Sentence denotes RESULTS:
TextSentencer_T8 871-1113 Sentence denotes Treatment with panobinostat induced heat shock protein 90 acetylation; depleted the levels of heat shock protein 90 client proteins, cyclin-dependent kinase 4, c-RAF, and AKT; and abrogated bortezomib-induced aggresome formation in MCL cells.
T8 871-1113 Sentence denotes Treatment with panobinostat induced heat shock protein 90 acetylation; depleted the levels of heat shock protein 90 client proteins, cyclin-dependent kinase 4, c-RAF, and AKT; and abrogated bortezomib-induced aggresome formation in MCL cells.
TextSentencer_T9 1114-1237 Sentence denotes Panobinostat also induced lethal UPR, associated with induction of CAAT/enhancer binding protein homologous protein (CHOP).
T9 1114-1237 Sentence denotes Panobinostat also induced lethal UPR, associated with induction of CAAT/enhancer binding protein homologous protein (CHOP).
TextSentencer_T10 1238-1324 Sentence denotes Conversely, knockdown of CHOP attenuated panobinostat-induced cell death of MCL cells.
T10 1238-1324 Sentence denotes Conversely, knockdown of CHOP attenuated panobinostat-induced cell death of MCL cells.
TextSentencer_T11 1325-1537 Sentence denotes Compared with each agent alone, cotreatment with panobinostat increased bortezomib-induced expression of CHOP and NOXA, as well as increased bortezomib-induced UPR and apoptosis of cultured and primary MCL cells.
T11 1325-1537 Sentence denotes Compared with each agent alone, cotreatment with panobinostat increased bortezomib-induced expression of CHOP and NOXA, as well as increased bortezomib-induced UPR and apoptosis of cultured and primary MCL cells.
TextSentencer_T12 1538-1704 Sentence denotes Cotreatment with panobinostat also increased bortezomib-mediated in vivo tumor growth inhibition and improved survival of mice bearing human Z138C MCL cell xenograft.
T12 1538-1704 Sentence denotes Cotreatment with panobinostat also increased bortezomib-mediated in vivo tumor growth inhibition and improved survival of mice bearing human Z138C MCL cell xenograft.
TextSentencer_T13 1705-1716 Sentence denotes CONCLUSION:
T13 1705-1716 Sentence denotes CONCLUSION:
TextSentencer_T14 1717-1874 Sentence denotes These findings suggest that increased UPR and induction of CHOP are involved in enhanced anti-MCL activity of the combination of panobinostat and bortezomib.
T14 1717-1874 Sentence denotes These findings suggest that increased UPR and induction of CHOP are involved in enhanced anti-MCL activity of the combination of panobinostat and bortezomib.