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PubMed:20622016 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
T1 0-115 Sentence denotes EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
TextSentencer_T2 116-238 Sentence denotes Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer.
T2 116-238 Sentence denotes Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer.
TextSentencer_T3 239-387 Sentence denotes Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis.
T3 239-387 Sentence denotes Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis.
TextSentencer_T4 388-480 Sentence denotes However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis.
T4 388-480 Sentence denotes However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis.
TextSentencer_T5 481-650 Sentence denotes In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells.
T5 481-650 Sentence denotes In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells.
TextSentencer_T6 651-852 Sentence denotes Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth.
T6 651-852 Sentence denotes Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth.
TextSentencer_T7 853-1003 Sentence denotes Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells.
T7 853-1003 Sentence denotes Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells.
TextSentencer_T8 1004-1250 Sentence denotes Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
T8 1004-1250 Sentence denotes Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.