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PubMed:20558831 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes COL4A1 mutations as a monogenic cause of cerebral small vessel disease: a systematic review.
T1 0-92 Sentence denotes COL4A1 mutations as a monogenic cause of cerebral small vessel disease: a systematic review.
TextSentencer_T2 93-116 Sentence denotes BACKGROUND AND PURPOSE:
T2 93-116 Sentence denotes BACKGROUND AND PURPOSE:
TextSentencer_T3 117-191 Sentence denotes A number of single gene disorders can cause cerebral small vessel disease.
T3 117-191 Sentence denotes A number of single gene disorders can cause cerebral small vessel disease.
TextSentencer_T4 192-453 Sentence denotes Mutations in the COL4A1 gene encoding the type IV collagen alpha 1 chain, which are already associated with porencephaly and infantile hemiparesis, have been recently recognized as a further monogenic cause of small vessel disease that can present in adulthood.
T4 192-453 Sentence denotes Mutations in the COL4A1 gene encoding the type IV collagen alpha 1 chain, which are already associated with porencephaly and infantile hemiparesis, have been recently recognized as a further monogenic cause of small vessel disease that can present in adulthood.
TextSentencer_T5 454-462 Sentence denotes METHODS:
T5 454-462 Sentence denotes METHODS:
TextSentencer_T6 463-623 Sentence denotes We performed a systematic review of published data from 1966 to January 8, 2010 to characterize the features of small vessel disease seen with COL4A1 mutations.
T6 463-623 Sentence denotes We performed a systematic review of published data from 1966 to January 8, 2010 to characterize the features of small vessel disease seen with COL4A1 mutations.
TextSentencer_T7 624-632 Sentence denotes RESULTS:
T7 624-632 Sentence denotes RESULTS:
TextSentencer_T8 633-679 Sentence denotes We identified a total of 52 mutation carriers.
T8 633-679 Sentence denotes We identified a total of 52 mutation carriers.
TextSentencer_T9 680-850 Sentence denotes A history of stroke was reported in 9 subjects (17.3%); in 6 cases it was attributable to subcortical hemorrhage and in 3 cases it was attributable to lacunar infarction.
T9 680-850 Sentence denotes A history of stroke was reported in 9 subjects (17.3%); in 6 cases it was attributable to subcortical hemorrhage and in 3 cases it was attributable to lacunar infarction.
TextSentencer_T10 851-970 Sentence denotes Stroke often occurred as first presentation of the disease, with a mean age of onset of 36.1 (SD, 12.95; range, 14-49).
T10 851-970 Sentence denotes Stroke often occurred as first presentation of the disease, with a mean age of onset of 36.1 (SD, 12.95; range, 14-49).
TextSentencer_T11 971-1082 Sentence denotes Hemorrhages, often recurrent, have been associated with physical trauma and activity and anticoagulant therapy.
T11 971-1082 Sentence denotes Hemorrhages, often recurrent, have been associated with physical trauma and activity and anticoagulant therapy.
TextSentencer_T12 1083-1254 Sentence denotes Brain imaging showed frequent leukoaraiosis (63.5%), microbleeds that are usually subcortical (52.9%), lacunar infarction (13.5%), and dilated perivascular spaces (19.2%).
T12 1083-1254 Sentence denotes Brain imaging showed frequent leukoaraiosis (63.5%), microbleeds that are usually subcortical (52.9%), lacunar infarction (13.5%), and dilated perivascular spaces (19.2%).
TextSentencer_T13 1255-1340 Sentence denotes Extensive leukoaraiosis was seen in a number of asymptomatic adult mutation carriers.
T13 1255-1340 Sentence denotes Extensive leukoaraiosis was seen in a number of asymptomatic adult mutation carriers.
TextSentencer_T14 1341-1420 Sentence denotes Asymptomatic intracranial aneurysms were common (44.4% of 18 with angiography).
T14 1341-1420 Sentence denotes Asymptomatic intracranial aneurysms were common (44.4% of 18 with angiography).
TextSentencer_T15 1421-1516 Sentence denotes Migraine (with and without aura) was reported in 10 subjects, with a mean age at onset of 31.7.
T15 1421-1516 Sentence denotes Migraine (with and without aura) was reported in 10 subjects, with a mean age at onset of 31.7.
TextSentencer_T16 1517-1623 Sentence denotes Systemic features are also frequent, affecting the eye (10/21, 47.6%), kidney (15.4%), and muscle (15.4%).
T16 1517-1623 Sentence denotes Systemic features are also frequent, affecting the eye (10/21, 47.6%), kidney (15.4%), and muscle (15.4%).
TextSentencer_T17 1624-1828 Sentence denotes CONCLUSIONS: COL4A1 is a further cause of familial vasculopathy and may present with stroke, ischemic as well as hemorrhagic, in adult life and with radiological features of leukoaraiosis and microbleeds.
T17 1624-1828 Sentence denotes CONCLUSIONS: COL4A1 is a further cause of familial vasculopathy and may present with stroke, ischemic as well as hemorrhagic, in adult life and with radiological features of leukoaraiosis and microbleeds.