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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.
T1 0-105 Sentence denotes Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.
T1 0-105 Sentence denotes Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.
TextSentencer_T2 106-222 Sentence denotes Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility.
T2 106-222 Sentence denotes Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility.
T2 106-222 Sentence denotes Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility.
TextSentencer_T3 223-309 Sentence denotes Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation.
T3 223-309 Sentence denotes Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation.
T3 223-309 Sentence denotes Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation.
TextSentencer_T4 310-542 Sentence denotes Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes.
T4 310-542 Sentence denotes Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes.
T4 310-542 Sentence denotes Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat adult cardiomyocytes.
TextSentencer_T5 543-739 Sentence denotes Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation.
T5 543-739 Sentence denotes Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation.
T5 543-739 Sentence denotes Studies using enzymatic labeling and co-immunoprecipitation of wild type and a series of mutants of PLN showed that PLN was O-GlcNAcylated and Ser(16) of PLN might be the site for O-GlcNAcylation.
TextSentencer_T6 740-928 Sentence denotes In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells.
T6 740-928 Sentence denotes In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells.
T6 740-928 Sentence denotes In cardiomyocytes treated with O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), the O-GlcNAcylation was significantly increased compared to non-treated cells.
TextSentencer_T7 929-988 Sentence denotes Simultaneously, Ser(16)-phosphorylation of PLN was reduced.
T7 929-988 Sentence denotes Simultaneously, Ser(16)-phosphorylation of PLN was reduced.
T7 929-988 Sentence denotes Simultaneously, Ser(16)-phosphorylation of PLN was reduced.
TextSentencer_T8 989-1171 Sentence denotes In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls.
T8 989-1171 Sentence denotes In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls.
T8 989-1171 Sentence denotes In Chinese hamster ovary cells where PLN cDNA and O-GlcNAc transferase siRNA were co-transfected, the Ser(16)-phosphorylation of PLN was significantly increased compared to controls.
TextSentencer_T9 1172-1243 Sentence denotes The same results were observed in heart homogenates from diabetic rats.
T9 1172-1243 Sentence denotes The same results were observed in heart homogenates from diabetic rats.
T9 1172-1243 Sentence denotes The same results were observed in heart homogenates from diabetic rats.
TextSentencer_T10 1244-1390 Sentence denotes In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes.
T10 1244-1390 Sentence denotes In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes.
T10 1244-1390 Sentence denotes In a co-immunoprecipitation of PLN with SERCA2a, the physical interaction between the two proteins was increased in PUGNAc-treated cardiomyocytes.
TextSentencer_T11 1391-1584 Sentence denotes Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine.
T11 1391-1584 Sentence denotes Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine.
T11 1391-1584 Sentence denotes Unlike non-treated cells, the activity of SERCA2a and the profiles of calcium transients in PUGNAc-treated cardiomyocytes were not significantly changed even after treatment with catecholamine.
TextSentencer_T12 1585-1738 Sentence denotes These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function.
T12 1585-1738 Sentence denotes These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function.
T12 1585-1738 Sentence denotes These data suggest that PLN is O-GlcNAcylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function.
TextSentencer_T13 1739-1910 Sentence denotes This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes.
T13 1739-1910 Sentence denotes This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes.
T13 1739-1910 Sentence denotes This might define a novel mechanism by which PLN regulation of SERCA2a is altered under conditions where O-GlcNAcylation is increased, such as those occurring in diabetes.