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PubMed:20335448 JSONTXT 34 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-174 Sentence denotes A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.
T1 0-174 Sentence denotes A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.
TextSentencer_T2 175-183 Sentence denotes CONTEXT:
T2 175-183 Sentence denotes CONTEXT:
TextSentencer_T3 184-392 Sentence denotes Generalized glucocorticoid resistance syndrome is a rare familial or sporadic condition characterized by partial insensitivity to glucocorticoids, caused by mutations in the glucocorticoid receptor (GR) gene.
T3 184-392 Sentence denotes Generalized glucocorticoid resistance syndrome is a rare familial or sporadic condition characterized by partial insensitivity to glucocorticoids, caused by mutations in the glucocorticoid receptor (GR) gene.
TextSentencer_T4 393-600 Sentence denotes Most of the reported cases are adults, demonstrating symptoms associated with mineralocorticoid and/or adrenal androgen excess caused by compensatively increased secretion of the adrenocorticotropic hormone.
T4 393-600 Sentence denotes Most of the reported cases are adults, demonstrating symptoms associated with mineralocorticoid and/or adrenal androgen excess caused by compensatively increased secretion of the adrenocorticotropic hormone.
TextSentencer_T5 601-609 Sentence denotes PATIENT:
T5 601-609 Sentence denotes PATIENT:
TextSentencer_T6 610-701 Sentence denotes We identified a new 2-yr-old female case of generalized glucocorticoid resistance syndrome.
T6 610-701 Sentence denotes We identified a new 2-yr-old female case of generalized glucocorticoid resistance syndrome.
TextSentencer_T7 702-801 Sentence denotes The patient (TJ) presented with a generalized seizure associated with hypoglycemia and hypokalemia.
T7 702-801 Sentence denotes The patient (TJ) presented with a generalized seizure associated with hypoglycemia and hypokalemia.
TextSentencer_T8 802-927 Sentence denotes She also had hypertension and premature pubarche, whereas dexamethasone effectively suppressed these clinical manifestations.
T8 802-927 Sentence denotes She also had hypertension and premature pubarche, whereas dexamethasone effectively suppressed these clinical manifestations.
TextSentencer_T9 928-936 Sentence denotes RESULTS:
T9 928-936 Sentence denotes RESULTS:
TextSentencer_T10 937-1168 Sentence denotes The patient's GR gene had a heterozygotic mutation (G-->A) at nucleotide position 2141 (exon 8), which resulted in substitution of arginine by glutamine at amino acid position 714 in the ligand-binding domain (LBD) of the GR alpha.
T10 937-1168 Sentence denotes The patient's GR gene had a heterozygotic mutation (G-->A) at nucleotide position 2141 (exon 8), which resulted in substitution of arginine by glutamine at amino acid position 714 in the ligand-binding domain (LBD) of the GR alpha.
TextSentencer_T11 1169-1320 Sentence denotes Molecular analysis revealed that the mutant receptor had significantly impaired transactivation activity with a 2-fold reduction in affinity to ligand.
T11 1169-1320 Sentence denotes Molecular analysis revealed that the mutant receptor had significantly impaired transactivation activity with a 2-fold reduction in affinity to ligand.
TextSentencer_T12 1321-1451 Sentence denotes It showed attenuated transactivation of the activation function (AF)-2 and reduced binding to a p160 nuclear receptor coactivator.
T12 1321-1451 Sentence denotes It showed attenuated transactivation of the activation function (AF)-2 and reduced binding to a p160 nuclear receptor coactivator.
TextSentencer_T13 1452-1726 Sentence denotes Computer-based structural analysis revealed that replacement of arginine by glutamine at position 714 transmitted a conformational change to the LBD and the AF-2 transactivation surface, resulting in a decreased binding affinity to ligand and to the LXXLL coactivator motif.
T13 1452-1726 Sentence denotes Computer-based structural analysis revealed that replacement of arginine by glutamine at position 714 transmitted a conformational change to the LBD and the AF-2 transactivation surface, resulting in a decreased binding affinity to ligand and to the LXXLL coactivator motif.
TextSentencer_T14 1727-1739 Sentence denotes CONCLUSIONS:
T14 1727-1739 Sentence denotes CONCLUSIONS:
TextSentencer_T15 1740-2012 Sentence denotes Dexamethasone treatment is effective in controlling the premature pubarche, hypoglycemia, hypertension, and hypokalemia in this child case, wherein arginine 714 plays a key role in the proper formation of the ligand-binding pocket and the AF-2 surface of the GR alpha LBD.
T15 1740-2012 Sentence denotes Dexamethasone treatment is effective in controlling the premature pubarche, hypoglycemia, hypertension, and hypokalemia in this child case, wherein arginine 714 plays a key role in the proper formation of the ligand-binding pocket and the AF-2 surface of the GR alpha LBD.