> top > projects > sentences > docs > PubMed:20332088 > annotations
sentences Home  

PubMed:20332088 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant.
T2 109-262 Sentence denotes Coloration is one of the most variable characters in animals and provides rich material for studying the developmental genetic basis of pigment patterns.
T3 263-355 Sentence denotes In the silkworm, more than 100 gene mutation systems are related to aberrant color patterns.
T4 356-488 Sentence denotes The melanism (mln) is a rare body color mutant that exhibits an easily distinguishable phenotype in both larval and adult silkworms.
T5 489-700 Sentence denotes By positional cloning, we identified the candidate gene of the mln locus, Bm-iAANAT, whose homologous gene (Dat) converts dopamine into N-acetyldopamine, a precursor for N-acetyldopamine sclerotin in Drosophila.
T6 701-848 Sentence denotes In the mln mutant, two types of abnormal Bm-iAANAT transcripts were identified, whose expression levels are markedly lower than the wild type (WT).
T7 849-1048 Sentence denotes Moreover, dopamine content was approximately twice as high in the sclerified tissues (head, thoracic legs, and anal plate) of the mutant as in WT, resulting in phenotypic differences between the two.
T8 1049-1258 Sentence denotes Quantitative reverse transcription PCR analyses showed that other genes involved in the melanin metabolism pathway were regulated by the aberrant Bm-iAANAT activity in mln mutant in different ways and degrees.
T9 1259-1451 Sentence denotes We therefore propose that greater accumulation of dopamine results from the functional deficiency of Bm-iAANAT in the mutant, causing a darker pattern in the sclerified regions than in the WT.
T10 1452-1565 Sentence denotes In summary, our results indicate that Bm-iAANAT is responsible for the color pattern of the silkworm mutant, mln.
T11 1566-1705 Sentence denotes To our knowledge, this is the first report showing a role for arylalkylamine-N-acetyltransferases in color pattern mutation in Lepidoptera.