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PubMed:20332085 JSONTXT 43 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-154 Sentence denotes Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.
T1 0-154 Sentence denotes Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.
TextSentencer_T2 155-279 Sentence denotes The cyclin-dependent kinase inhibitor p27(Kip1) plays a critical role in regulating entry into and exit from the cell cycle.
T2 155-279 Sentence denotes The cyclin-dependent kinase inhibitor p27(Kip1) plays a critical role in regulating entry into and exit from the cell cycle.
TextSentencer_T3 280-363 Sentence denotes Post-transcriptional regulation of p27(Kip1) expression is of significant interest.
T3 280-363 Sentence denotes Post-transcriptional regulation of p27(Kip1) expression is of significant interest.
TextSentencer_T4 364-569 Sentence denotes The embryonic lethal abnormal vision (ELAV)-like RNA-binding protein HuR is thought be important for the translation of p27(Kip1), however, different reports attributed diametrically opposite roles to HuR.
T4 364-569 Sentence denotes The embryonic lethal abnormal vision (ELAV)-like RNA-binding protein HuR is thought be important for the translation of p27(Kip1), however, different reports attributed diametrically opposite roles to HuR.
TextSentencer_T5 570-664 Sentence denotes We report here an alternative mechanism wherein HuR regulates stability of the p27(Kip1) mRNA.
T5 570-664 Sentence denotes We report here an alternative mechanism wherein HuR regulates stability of the p27(Kip1) mRNA.
TextSentencer_T6 665-815 Sentence denotes Specifically, human and mouse p27(Kip1) mRNAs interact with HuR protein through multiple U-rich elements in both 5' and 3' untranslated regions (UTR).
T6 665-815 Sentence denotes Specifically, human and mouse p27(Kip1) mRNAs interact with HuR protein through multiple U-rich elements in both 5' and 3' untranslated regions (UTR).
TextSentencer_T7 816-940 Sentence denotes These interactions, which occur in vitro and in vivo, stabilize p27(Kip1) mRNA and play a critical role in its accumulation.
T7 816-940 Sentence denotes These interactions, which occur in vitro and in vivo, stabilize p27(Kip1) mRNA and play a critical role in its accumulation.
TextSentencer_T8 941-1057 Sentence denotes Deleting HuR binding sites or knocking down HuR expression destabilizes p27(Kip1) mRNA and reduces its accumulation.
T8 941-1057 Sentence denotes Deleting HuR binding sites or knocking down HuR expression destabilizes p27(Kip1) mRNA and reduces its accumulation.
TextSentencer_T9 1058-1227 Sentence denotes We also identified a CT repeat in the 5' UTR of full-length p27(Kip1) mRNA isoforms that interact with a approximately 41-kDa protein and represses p27(Kip1) expression.
T9 1058-1227 Sentence denotes We also identified a CT repeat in the 5' UTR of full-length p27(Kip1) mRNA isoforms that interact with a approximately 41-kDa protein and represses p27(Kip1) expression.
TextSentencer_T10 1228-1366 Sentence denotes This CT-rich element and diffuse elements in the 3' UTR regulate post-transcriptional expression of p27(Kip1) at the level of translation.
T10 1228-1366 Sentence denotes This CT-rich element and diffuse elements in the 3' UTR regulate post-transcriptional expression of p27(Kip1) at the level of translation.
TextSentencer_T11 1367-1555 Sentence denotes This is the first demonstration that HuR-dependent mRNA stability and HuR-independent mRNA translation plays a critical role in the regulation of post-transcriptional p27(Kip1) expression.
T11 1367-1555 Sentence denotes This is the first demonstration that HuR-dependent mRNA stability and HuR-independent mRNA translation plays a critical role in the regulation of post-transcriptional p27(Kip1) expression.