| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-59 |
Sentence |
denotes |
A novel LZAP-binding protein, NLBP, inhibits cell invasion. |
| T2 |
60-254 |
Sentence |
denotes |
LXXLL/leucine zipper-containing alternative reading frame (ARF)-binding protein (LZAP) was recently shown to function as a tumor suppressor through inhibition of the NF-kappaB signaling pathway. |
| T3 |
255-391 |
Sentence |
denotes |
LZAP is also known as a negative regulator of cell invasion, and its expression was demonstrated to be reduced in several tumor tissues. |
| T4 |
392-484 |
Sentence |
denotes |
However, the molecular mechanism of the negative effect of LZAP on cell invasion is unclear. |
| T5 |
485-584 |
Sentence |
denotes |
In this study, we identify NLBP as a novel LZAP-binding protein using tandem affinity purification. |
| T6 |
585-682 |
Sentence |
denotes |
We demonstrate the negative effects of NLBP on cell invasion and the NF-kappaB signaling pathway. |
| T7 |
683-883 |
Sentence |
denotes |
NLBP expression was not detected in hepatocellular carcinoma cells with strong invasive activity, whereas its expression was detected in a hepatocellular carcinoma cell line with no invasive activity. |
| T8 |
884-1022 |
Sentence |
denotes |
We also demonstrate that these two proteins mutually affect the stability of each other by inhibiting ubiquitination of the other protein. |
| T9 |
1023-1208 |
Sentence |
denotes |
Based on these results, we suggest that NLBP may act as a novel tumor suppressor by inhibiting cell invasion, blocking NF-kappaB signaling, and increasing stability of the LZAP protein. |
