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PubMed:20142525 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-87 Sentence denotes Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
T1 0-87 Sentence denotes Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
TextSentencer_T2 88-98 Sentence denotes OBJECTIVE:
T2 88-98 Sentence denotes OBJECTIVE:
TextSentencer_T3 99-280 Sentence denotes To characterize a kindred with a familial neurodegenerative disorder associated with a mutation in progranulin (PGRN), with emphasis on the unique clinical features in this kindred.
T3 99-280 Sentence denotes To characterize a kindred with a familial neurodegenerative disorder associated with a mutation in progranulin (PGRN), with emphasis on the unique clinical features in this kindred.
TextSentencer_T4 281-288 Sentence denotes DESIGN:
T4 281-288 Sentence denotes DESIGN:
TextSentencer_T5 289-388 Sentence denotes Antemortem and postmortem characterization of a kindred with a familial neurodegenerative disorder.
T5 289-388 Sentence denotes Antemortem and postmortem characterization of a kindred with a familial neurodegenerative disorder.
TextSentencer_T6 389-397 Sentence denotes SETTING:
T6 389-397 Sentence denotes SETTING:
TextSentencer_T7 398-443 Sentence denotes Multispecialty group academic medical center.
T7 398-443 Sentence denotes Multispecialty group academic medical center.
TextSentencer_T8 444-453 Sentence denotes PATIENTS:
T8 444-453 Sentence denotes PATIENTS:
TextSentencer_T9 454-569 Sentence denotes Affected members of a kindred with dementia with or without parkinsonism associated with a unique mutation in PGRN.
T9 454-569 Sentence denotes Affected members of a kindred with dementia with or without parkinsonism associated with a unique mutation in PGRN.
TextSentencer_T10 570-591 Sentence denotes MAIN OUTCOME MEASURE:
T10 570-591 Sentence denotes MAIN OUTCOME MEASURE:
TextSentencer_T11 592-623 Sentence denotes Genotype-phenotype correlation.
T11 592-623 Sentence denotes Genotype-phenotype correlation.
TextSentencer_T12 624-632 Sentence denotes RESULTS:
T12 624-632 Sentence denotes RESULTS:
TextSentencer_T13 633-808 Sentence denotes Of 10 affected individuals identified, 6 presented with early amnestic symptoms which resulted in initial diagnoses of Alzheimer disease or amnestic mild cognitive impairment.
T13 633-808 Sentence denotes Of 10 affected individuals identified, 6 presented with early amnestic symptoms which resulted in initial diagnoses of Alzheimer disease or amnestic mild cognitive impairment.
TextSentencer_T14 809-892 Sentence denotes Some individuals presented with features characteristic of frontotemporal dementia.
T14 809-892 Sentence denotes Some individuals presented with features characteristic of frontotemporal dementia.
TextSentencer_T15 893-1043 Sentence denotes Mean age at onset was substantially younger in generation III (75.8 years; range, 69-80 years) than in generation II (60.7 years; range, 55-66 years).
T15 893-1043 Sentence denotes Mean age at onset was substantially younger in generation III (75.8 years; range, 69-80 years) than in generation II (60.7 years; range, 55-66 years).
TextSentencer_T16 1044-1118 Sentence denotes The pattern of cerebral atrophy varied widely in the affected individuals.
T16 1044-1118 Sentence denotes The pattern of cerebral atrophy varied widely in the affected individuals.
TextSentencer_T17 1119-1295 Sentence denotes Neuropathologic features in 6 individuals included frontotemporal lobar degeneration with ubiquitin-positive neuronal cytoplasmic and intranuclear inclusions (FTLD-U with NII).
T17 1119-1295 Sentence denotes Neuropathologic features in 6 individuals included frontotemporal lobar degeneration with ubiquitin-positive neuronal cytoplasmic and intranuclear inclusions (FTLD-U with NII).
TextSentencer_T18 1296-1496 Sentence denotes PGRN analysis revealed a single base pair deletion in exon 2 (c.154delA), which caused a frameshift (p.Thr52HisfsX2) and, therefore, creation of a premature termination codon and a likely null allele.
T18 1296-1496 Sentence denotes PGRN analysis revealed a single base pair deletion in exon 2 (c.154delA), which caused a frameshift (p.Thr52HisfsX2) and, therefore, creation of a premature termination codon and a likely null allele.
TextSentencer_T19 1497-1509 Sentence denotes CONCLUSIONS:
T19 1497-1509 Sentence denotes CONCLUSIONS:
TextSentencer_T20 1510-1753 Sentence denotes In this large kindred, most affected individuals had clinical presentations that resembled Alzheimer disease or amnestic mild cognitive impairment associated with a mutation in PGRN and underlying FTLD-U with NII neuropathologic abnormalities.
T20 1510-1753 Sentence denotes In this large kindred, most affected individuals had clinical presentations that resembled Alzheimer disease or amnestic mild cognitive impairment associated with a mutation in PGRN and underlying FTLD-U with NII neuropathologic abnormalities.
TextSentencer_T21 1754-1904 Sentence denotes This finding is in distinct contrast to previously reported kindreds, in which clinical presentations have typically been within the spectrum of FTLD.
T21 1754-1904 Sentence denotes This finding is in distinct contrast to previously reported kindreds, in which clinical presentations have typically been within the spectrum of FTLD.
TextSentencer_T22 1905-1999 Sentence denotes The basis for the large difference in age at onset between generations requires further study.
T22 1905-1999 Sentence denotes The basis for the large difference in age at onset between generations requires further study.