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PubMed:20032046 JSONTXT 54 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
T1 0-139 Sentence denotes Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937.
TextSentencer_T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
T2 140-318 Sentence denotes Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
TextSentencer_T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
T3 319-409 Sentence denotes Here, we report that clustering of Siglec-7 with a specific F(ab')(2) elicited cell death.
TextSentencer_T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
T4 410-578 Sentence denotes Interestingly, a truncated Siglec-7 lacking the cytosolic ITIM domain still induced the cell death, suggesting that the ITIMs are not essential for the death signaling.
TextSentencer_T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
T5 579-757 Sentence denotes Further analyses of the death signaling revealed that an oxygen radical scavenger, N-acetyl cysteine, completely inhibited the cell death, whereas a pancaspase inhibitor did not.
TextSentencer_T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
T6 758-931 Sentence denotes In addition, caspase-3 activation, DNA ladder formation, and nuclear condensation were not detected during the death process, suggesting that the cell death is nonapoptotic.
TextSentencer_T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
T7 932-1116 Sentence denotes To identify the critical region for the death signaling, we prepared a series of shuffling chimeras between Siglec-7 and Siglec-9, the latter of which did not transduce a death signal.
TextSentencer_T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
T8 1117-1280 Sentence denotes The critical region was mapped to the middle of the membrane-proximal C2-set domain, which contained only six amino acid differences between Siglec-7 and Siglec-9.
TextSentencer_T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
T9 1281-1415 Sentence denotes Point mutation analyses of each of these six amino acids revealed that four of the six amino acids were critical for the death signal.
TextSentencer_T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
T10 1416-1545 Sentence denotes A computer-assisted 3D modeling revealed that these four amino acids were proximally located on the surface of the C2-set domain.
TextSentencer_T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.
T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.
T11 1546-1672 Sentence denotes In conclusion, Siglec-7 induces nonapoptotic cell death, the signal for which is transduced by an extracellular C2-set domain.