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PubMed:19895223 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients.
T1 0-73 Sentence denotes GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients.
TextSentencer_T2 74-246 Sentence denotes The most important prognostic marker of survival and predictive marker of response to adjuvant chemotherapy in colon cancer patients is tumor cells in regional lymph nodes.
T2 74-246 Sentence denotes The most important prognostic marker of survival and predictive marker of response to adjuvant chemotherapy in colon cancer patients is tumor cells in regional lymph nodes.
TextSentencer_T3 247-490 Sentence denotes Despite their importance, standard techniques to assess nodal metastases remain imperfect, as approximately 30% of patients with histology-negative lymph nodes (pN0) die of recurrent disease, reflecting occult metastases that escape detection.
T3 247-490 Sentence denotes Despite their importance, standard techniques to assess nodal metastases remain imperfect, as approximately 30% of patients with histology-negative lymph nodes (pN0) die of recurrent disease, reflecting occult metastases that escape detection.
TextSentencer_T4 491-638 Sentence denotes These observations highlight the clinical need for novel, accurate approaches to detect occult lymph node metastases in patients with colon cancer.
T4 491-638 Sentence denotes These observations highlight the clinical need for novel, accurate approaches to detect occult lymph node metastases in patients with colon cancer.
TextSentencer_T5 639-787 Sentence denotes GUCY2C is a biomarker whose expression normally is restricted to intestinal cells, but is near universally overexpressed by colorectal cancer cells.
T5 639-787 Sentence denotes GUCY2C is a biomarker whose expression normally is restricted to intestinal cells, but is near universally overexpressed by colorectal cancer cells.
TextSentencer_T6 788-1037 Sentence denotes Recently, a prospective, multicenter, blinded clinical trial demonstrated for the first time that the prognostic utility of GUCY2C quantitative reverse transcriptase (qRT)-PCR to detect occult lymph node metastases in pN0 colorectal cancer patients.
T6 788-1037 Sentence denotes Recently, a prospective, multicenter, blinded clinical trial demonstrated for the first time that the prognostic utility of GUCY2C quantitative reverse transcriptase (qRT)-PCR to detect occult lymph node metastases in pN0 colorectal cancer patients.
TextSentencer_T7 1038-1206 Sentence denotes Molecular staging revealed that approximately 13% of pN0 patients were free of tumor cells, while approximately 87% had GUCY2C results that suggested occult metastases.
T7 1038-1206 Sentence denotes Molecular staging revealed that approximately 13% of pN0 patients were free of tumor cells, while approximately 87% had GUCY2C results that suggested occult metastases.
TextSentencer_T8 1207-1340 Sentence denotes The presence of occult lymph node metastases was the strongest independent predictor of time to recurrence and disease-free survival.
T8 1207-1340 Sentence denotes The presence of occult lymph node metastases was the strongest independent predictor of time to recurrence and disease-free survival.
TextSentencer_T9 1341-1502 Sentence denotes These observations establish the utility of molecular detection of occult lymph node metastases for estimating prognostic risk in pN0 colorectal cancer patients.
T9 1341-1502 Sentence denotes These observations establish the utility of molecular detection of occult lymph node metastases for estimating prognostic risk in pN0 colorectal cancer patients.
TextSentencer_T10 1503-1857 Sentence denotes Advancing this molecular diagnostic into staging paradigms in clinical laboratories will require validation in independent patient populations, definition of the relationship between the quantity of occult tumor metastases and risk, and determination of the utility of GUCY2C qRT-PCR to identify pN0 patients who might benefit from adjuvant chemotherapy.
T10 1503-1857 Sentence denotes Advancing this molecular diagnostic into staging paradigms in clinical laboratories will require validation in independent patient populations, definition of the relationship between the quantity of occult tumor metastases and risk, and determination of the utility of GUCY2C qRT-PCR to identify pN0 patients who might benefit from adjuvant chemotherapy.