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PubMed:19567472 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes PML-IV functions as a negative regulator of telomerase by interacting with TERT.
T1 0-80 Sentence denotes PML-IV functions as a negative regulator of telomerase by interacting with TERT.
TextSentencer_T2 81-163 Sentence denotes Maintaining proper telomere length requires the presence of the telomerase enzyme.
T2 81-163 Sentence denotes Maintaining proper telomere length requires the presence of the telomerase enzyme.
TextSentencer_T3 164-356 Sentence denotes Here we show that telomerase reverse transcriptase (TERT), a catalytic component of telomerase, is recruited to promyelocytic leukemia (PML) nuclear bodies through its interaction with PML-IV.
T3 164-356 Sentence denotes Here we show that telomerase reverse transcriptase (TERT), a catalytic component of telomerase, is recruited to promyelocytic leukemia (PML) nuclear bodies through its interaction with PML-IV.
TextSentencer_T4 357-528 Sentence denotes Treatment of interferon-alpha (IFNalpha) in H1299 cells resulted in the increase of PML proteins with a concurrent decrease of telomerase activity, as previously reported.
T4 357-528 Sentence denotes Treatment of interferon-alpha (IFNalpha) in H1299 cells resulted in the increase of PML proteins with a concurrent decrease of telomerase activity, as previously reported.
TextSentencer_T5 529-656 Sentence denotes PML depletion, however, stimulated telomerase activity that had been inhibited by IFNalpha with no changes in TERT mRNA levels.
T5 529-656 Sentence denotes PML depletion, however, stimulated telomerase activity that had been inhibited by IFNalpha with no changes in TERT mRNA levels.
TextSentencer_T6 657-777 Sentence denotes Upon treatment with IFNalpha, exogenous TERT localized to PML nuclear bodies and binding between TERT and PML increased.
T6 657-777 Sentence denotes Upon treatment with IFNalpha, exogenous TERT localized to PML nuclear bodies and binding between TERT and PML increased.
TextSentencer_T7 778-876 Sentence denotes Immunoprecipitation and immunofluorescence analyses showed that TERT specifically bound to PML-IV.
T7 778-876 Sentence denotes Immunoprecipitation and immunofluorescence analyses showed that TERT specifically bound to PML-IV.
TextSentencer_T8 877-1020 Sentence denotes Residues 553-633 of the C-terminal region of PML-IV were required for its interaction with the TERT region spanning residues 1-350 and 595-946.
T8 877-1020 Sentence denotes Residues 553-633 of the C-terminal region of PML-IV were required for its interaction with the TERT region spanning residues 1-350 and 595-946.
TextSentencer_T9 1021-1130 Sentence denotes The expression of PML-IV and its deletion mutant, 553-633, suppressed intrinsic telomerase activity in H1299.
T9 1021-1130 Sentence denotes The expression of PML-IV and its deletion mutant, 553-633, suppressed intrinsic telomerase activity in H1299.
TextSentencer_T10 1131-1263 Sentence denotes TERT-mediated immunoprecipitation of PML or the 553-633 fragment demonstrated that these interactions inhibited telomerase activity.
T10 1131-1263 Sentence denotes TERT-mediated immunoprecipitation of PML or the 553-633 fragment demonstrated that these interactions inhibited telomerase activity.
TextSentencer_T11 1264-1381 Sentence denotes H1299 cell lines stably expressing PML-IV displayed decreased telomerase activity with no change of TERT mRNA levels.
T11 1264-1381 Sentence denotes H1299 cell lines stably expressing PML-IV displayed decreased telomerase activity with no change of TERT mRNA levels.
TextSentencer_T12 1382-1453 Sentence denotes Accordingly, telomere length of PML-IV stable cell lines was shortened.
T12 1382-1453 Sentence denotes Accordingly, telomere length of PML-IV stable cell lines was shortened.
TextSentencer_T13 1454-1559 Sentence denotes These results indicate that PML-IV is a negative regulator of telomerase in the post-translational state.
T13 1454-1559 Sentence denotes These results indicate that PML-IV is a negative regulator of telomerase in the post-translational state.