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PubMed:19545858 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.
T1 0-117 Sentence denotes Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.
TextSentencer_T2 118-129 Sentence denotes BACKGROUND:
T2 118-129 Sentence denotes BACKGROUND:
TextSentencer_T3 130-250 Sentence denotes A number of studies have suggested deficits in myelination and glial gene expression in different psychiatric disorders.
T3 130-250 Sentence denotes A number of studies have suggested deficits in myelination and glial gene expression in different psychiatric disorders.
TextSentencer_T4 251-421 Sentence denotes We examined the brain expression and genetic/epigenetic regulation of QKI, an oligodendrocyte-specific RNA binding protein important for cell development and myelination.
T4 251-421 Sentence denotes We examined the brain expression and genetic/epigenetic regulation of QKI, an oligodendrocyte-specific RNA binding protein important for cell development and myelination.
TextSentencer_T5 422-430 Sentence denotes METHODS:
T5 422-430 Sentence denotes METHODS:
TextSentencer_T6 431-623 Sentence denotes The microarray-based expression of QKI was evaluated in cortical and subcortical brain regions from suicide victims with a diagnosis of major depression (n = 16) and control subjects (n = 13).
T6 431-623 Sentence denotes The microarray-based expression of QKI was evaluated in cortical and subcortical brain regions from suicide victims with a diagnosis of major depression (n = 16) and control subjects (n = 13).
TextSentencer_T7 624-790 Sentence denotes These findings were also assessed with a real-time (quantitative polymerase chain reaction [qPCR]) approach, with QKI protein levels evaluated through immunoblotting.
T7 624-790 Sentence denotes These findings were also assessed with a real-time (quantitative polymerase chain reaction [qPCR]) approach, with QKI protein levels evaluated through immunoblotting.
TextSentencer_T8 791-908 Sentence denotes Identification of a QKI promoter sequence was then used to examine genetic and epigenetic variation at the QKI locus.
T8 791-908 Sentence denotes Identification of a QKI promoter sequence was then used to examine genetic and epigenetic variation at the QKI locus.
TextSentencer_T9 909-917 Sentence denotes RESULTS:
T9 909-917 Sentence denotes RESULTS:
TextSentencer_T10 918-1162 Sentence denotes The messenger RNA (mRNA) levels of multiple transcripts of QKI were evaluated on Affymetrix microarrays, revealing significant reductions in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
T10 918-1162 Sentence denotes The messenger RNA (mRNA) levels of multiple transcripts of QKI were evaluated on Affymetrix microarrays, revealing significant reductions in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
TextSentencer_T11 1163-1284 Sentence denotes Microarray findings were confirmed by qPCR, and reduced expression of QKI protein was identified in orbitofrontal cortex.
T11 1163-1284 Sentence denotes Microarray findings were confirmed by qPCR, and reduced expression of QKI protein was identified in orbitofrontal cortex.
TextSentencer_T12 1285-1484 Sentence denotes Analysis of promoter variation and methylation state in a subset of individuals did not identify differences at the genetic or epigenetic level between depressed suicide victims and control subjects.
T12 1285-1484 Sentence denotes Analysis of promoter variation and methylation state in a subset of individuals did not identify differences at the genetic or epigenetic level between depressed suicide victims and control subjects.
TextSentencer_T13 1485-1497 Sentence denotes CONCLUSIONS:
T13 1485-1497 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1498-1723 Sentence denotes The observation of consistent reductions in multiple isoforms of QKI mRNA in depressed suicide victims supports the growing body of evidence for a role of myelination-related deficits in the etiology of psychiatric disorders.
T14 1498-1723 Sentence denotes The observation of consistent reductions in multiple isoforms of QKI mRNA in depressed suicide victims supports the growing body of evidence for a role of myelination-related deficits in the etiology of psychiatric disorders.
TextSentencer_T15 1724-1960 Sentence denotes A specific role of QKI in this process is implied by its reduced expression and known interactions with genes involved in oligodendrocyte determination; however, QKI gene variation responsible for these changes remains to be identified.
T15 1724-1960 Sentence denotes A specific role of QKI in this process is implied by its reduced expression and known interactions with genes involved in oligodendrocyte determination; however, QKI gene variation responsible for these changes remains to be identified.