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PubMed:19261606 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
T1 0-102 Sentence denotes The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
T2 103-198 Sentence denotes The proper regulation of factors involved in mitosis is crucial to ensure normal cell division.
T2 103-198 Sentence denotes The proper regulation of factors involved in mitosis is crucial to ensure normal cell division.
T3 199-316 Sentence denotes Levels and activities of proteins are regulated in many ways, one of which is ubiquitin-mediated protein degradation.
T3 199-316 Sentence denotes Levels and activities of proteins are regulated in many ways, one of which is ubiquitin-mediated protein degradation.
T4 317-437 Sentence denotes E3 ubiquitin ligases are involved in targeting specific substrates for degradation by facilitating their ubiquitination.
T4 317-437 Sentence denotes E3 ubiquitin ligases are involved in targeting specific substrates for degradation by facilitating their ubiquitination.
T5 438-589 Sentence denotes In seeking to elucidate additional biological roles for Cul3 we performed a two-hybrid screen and identified Ctb9/KLHDC5 as a Cul3-interacting protein.
T5 438-589 Sentence denotes In seeking to elucidate additional biological roles for Cul3 we performed a two-hybrid screen and identified Ctb9/KLHDC5 as a Cul3-interacting protein.
T6 590-736 Sentence denotes Overexpression of Ctb9/KLHDC5 resulted in an increase in microtubule density as well as persistent microtubule bridges between post-mitotic cells.
T6 590-736 Sentence denotes Overexpression of Ctb9/KLHDC5 resulted in an increase in microtubule density as well as persistent microtubule bridges between post-mitotic cells.
T7 737-833 Sentence denotes Conversely, down-regulation of Ctb9/KLHDC5 showed a pronounced reduction in microtubule density.
T7 737-833 Sentence denotes Conversely, down-regulation of Ctb9/KLHDC5 showed a pronounced reduction in microtubule density.
T8 834-969 Sentence denotes Based on these observations, we examined the interactions between Cul3, Ctb9/KLHDC5, and the microtubule-severing protein, p60/katanin.
T8 834-969 Sentence denotes Based on these observations, we examined the interactions between Cul3, Ctb9/KLHDC5, and the microtubule-severing protein, p60/katanin.
T9 970-1113 Sentence denotes Here we show that p60/katanin interacts with a complex consisting of Cul3 and Ctb9/KLHDC5, which results in ubiquitin laddering of p60/katanin.
T9 970-1113 Sentence denotes Here we show that p60/katanin interacts with a complex consisting of Cul3 and Ctb9/KLHDC5, which results in ubiquitin laddering of p60/katanin.
T10 1114-1291 Sentence denotes Also, Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal.
T10 1114-1291 Sentence denotes Also, Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal.
T11 1292-1456 Sentence denotes We demonstrate a novel regulatory mechanism for p60/katanin that occurs at the level of targeted proteolysis to allow normal mitotic progression in mammalian cells.
T11 1292-1456 Sentence denotes We demonstrate a novel regulatory mechanism for p60/katanin that occurs at the level of targeted proteolysis to allow normal mitotic progression in mammalian cells.