| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-78 |
Sentence |
denotes |
Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells. |
| T1 |
0-78 |
Sentence |
denotes |
Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells. |
| TextSentencer_T2 |
79-206 |
Sentence |
denotes |
Multiple isoforms of mammalian alpha-mannosidases are active in the pathways of N-linked glycoprotein synthesis and catabolism. |
| T2 |
79-206 |
Sentence |
denotes |
Multiple isoforms of mammalian alpha-mannosidases are active in the pathways of N-linked glycoprotein synthesis and catabolism. |
| TextSentencer_T3 |
207-343 |
Sentence |
denotes |
They differ in specificity, function and location within the cell and can be selectively inhibited by imino sugar monosaccharide mimics. |
| T3 |
207-343 |
Sentence |
denotes |
They differ in specificity, function and location within the cell and can be selectively inhibited by imino sugar monosaccharide mimics. |
| TextSentencer_T4 |
344-508 |
Sentence |
denotes |
Previously, a series of structurally related novel 7-membered iminocyclitols were synthesised and found to be inhibitors of alpha-mannosidase using in vitro assays. |
| T4 |
344-508 |
Sentence |
denotes |
Previously, a series of structurally related novel 7-membered iminocyclitols were synthesised and found to be inhibitors of alpha-mannosidase using in vitro assays. |
| TextSentencer_T5 |
509-769 |
Sentence |
denotes |
The present study aimed to delineate alpha-mannosidases hydrolytic pathways in azepane inhibitor treated cells by the analysis of free oligosaccharides (FOS) as markers of endoplasmic reticulum (ER), Golgi, lysosomal and cytosolic alpha-mannosidase activities. |
| T5 |
509-769 |
Sentence |
denotes |
The present study aimed to delineate alpha-mannosidases hydrolytic pathways in azepane inhibitor treated cells by the analysis of free oligosaccharides (FOS) as markers of endoplasmic reticulum (ER), Golgi, lysosomal and cytosolic alpha-mannosidase activities. |
| TextSentencer_T6 |
770-863 |
Sentence |
denotes |
Two compounds were identified as potent and selective cytosolic alpha-mannosidase inhibitors. |
| T6 |
770-863 |
Sentence |
denotes |
Two compounds were identified as potent and selective cytosolic alpha-mannosidase inhibitors. |
| TextSentencer_T7 |
864-1006 |
Sentence |
denotes |
Two related compounds were shown to be potent inhibitors of lysosomal alpha-mannosidase with different potencies towards alpha1,6 mannosidase. |
| T7 |
864-1006 |
Sentence |
denotes |
Two related compounds were shown to be potent inhibitors of lysosomal alpha-mannosidase with different potencies towards alpha1,6 mannosidase. |
| TextSentencer_T8 |
1007-1147 |
Sentence |
denotes |
The specificities of these novel 7-membered imino sugars are related to differences in their structure and D: -mannose-like stereochemistry. |
| T8 |
1007-1147 |
Sentence |
denotes |
The specificities of these novel 7-membered imino sugars are related to differences in their structure and D: -mannose-like stereochemistry. |
| TextSentencer_T9 |
1148-1312 |
Sentence |
denotes |
Specific ER-mannosidase inhibition by kifunensine also reveals significant non-proteasomal degradation following FOS analysis and appears to be cell line dependent. |
| T9 |
1148-1312 |
Sentence |
denotes |
Specific ER-mannosidase inhibition by kifunensine also reveals significant non-proteasomal degradation following FOS analysis and appears to be cell line dependent. |
| TextSentencer_T10 |
1313-1434 |
Sentence |
denotes |
The availability of more selective inhibitors allows the pathways of N-linked oligosaccharide metabolism to be dissected. |
| T10 |
1313-1434 |
Sentence |
denotes |
The availability of more selective inhibitors allows the pathways of N-linked oligosaccharide metabolism to be dissected. |