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PubMed:19219548 JSONTXT 38 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
T1 0-125 Sentence denotes VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
TextSentencer_T2 126-202 Sentence denotes Angiogenesis is largely driven by vascular endothelial growth factor (VEGF).
T2 126-202 Sentence denotes Angiogenesis is largely driven by vascular endothelial growth factor (VEGF).
TextSentencer_T3 203-341 Sentence denotes However, the role of lipid second messengers such as lactosylceramide (LacCer) and LacCer synthase in angiogenesis is not well understood.
T3 203-341 Sentence denotes However, the role of lipid second messengers such as lactosylceramide (LacCer) and LacCer synthase in angiogenesis is not well understood.
TextSentencer_T4 342-474 Sentence denotes We have determined the distribution of various LacCer synthase mRNA transcripts using sequential analysis of gene expression (SAGE).
T4 342-474 Sentence denotes We have determined the distribution of various LacCer synthase mRNA transcripts using sequential analysis of gene expression (SAGE).
TextSentencer_T5 475-644 Sentence denotes Endothelial cells from colon cancer tissues had a 4.5-fold increase in a LacCer synthase transcript (beta1,4GalT-V) as compared to normal colon tissue endothelial cells.
T5 475-644 Sentence denotes Endothelial cells from colon cancer tissues had a 4.5-fold increase in a LacCer synthase transcript (beta1,4GalT-V) as compared to normal colon tissue endothelial cells.
TextSentencer_T6 645-778 Sentence denotes Consequently, our focus turned to understanding the role of this enzyme in regulating VEGF-induced angiogenesis in vitro and in vivo.
T6 645-778 Sentence denotes Consequently, our focus turned to understanding the role of this enzyme in regulating VEGF-induced angiogenesis in vitro and in vivo.
TextSentencer_T7 779-1056 Sentence denotes Herein, we show that in human endothelial cells, VEGF-induced angiogenesis is mitigated by dimethylsphingosine and suramin; inhibitors of sphingosine kinase 1(SphK-1) and sphingosine1-phosphate receptor 1(S1P (1)), respectively, and this were bypassed by LacCer but not by S1P.
T7 779-1056 Sentence denotes Herein, we show that in human endothelial cells, VEGF-induced angiogenesis is mitigated by dimethylsphingosine and suramin; inhibitors of sphingosine kinase 1(SphK-1) and sphingosine1-phosphate receptor 1(S1P (1)), respectively, and this were bypassed by LacCer but not by S1P.
TextSentencer_T8 1057-1295 Sentence denotes VEGF and basic fibroblast growth factor-induced angiogenesis was mitigated by PDMP; an inhibitor of glucosylceramide synthase and LacCer synthase in human umbilical vein endothelial cells (HUVEC) and human aortic endothelial cells (HAEC).
T8 1057-1295 Sentence denotes VEGF and basic fibroblast growth factor-induced angiogenesis was mitigated by PDMP; an inhibitor of glucosylceramide synthase and LacCer synthase in human umbilical vein endothelial cells (HUVEC) and human aortic endothelial cells (HAEC).
TextSentencer_T9 1296-1394 Sentence denotes Likewise, GalT-V gene ablation using corresponding siRNA also mitigated VEGF-induced angiogenesis.
T9 1296-1394 Sentence denotes Likewise, GalT-V gene ablation using corresponding siRNA also mitigated VEGF-induced angiogenesis.
TextSentencer_T10 1395-1545 Sentence denotes In Matrigel plug angiogenesis assay in nude mice, angiogenesis was markedly inhibited by D-PDMP with concordantly diminished LacCer synthase activity.
T10 1395-1545 Sentence denotes In Matrigel plug angiogenesis assay in nude mice, angiogenesis was markedly inhibited by D-PDMP with concordantly diminished LacCer synthase activity.
TextSentencer_T11 1546-1817 Sentence denotes Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.
T11 1546-1817 Sentence denotes Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.
TextSentencer_T12 1818-2047 Sentence denotes Since this enzyme is a target for VEGF action and LacCer serves as a lipid second messenger in inducing angiogenesis in vitro and in vivo, novel therapeutic approaches may be developed using our findings to mitigate colon cancer.
T12 1818-2047 Sentence denotes Since this enzyme is a target for VEGF action and LacCer serves as a lipid second messenger in inducing angiogenesis in vitro and in vivo, novel therapeutic approaches may be developed using our findings to mitigate colon cancer.