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PubMed:19176376 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-119 Sentence denotes A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.
T1 0-119 Sentence denotes A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.
TextSentencer_T2 120-184 Sentence denotes The tumor antigen NY-ESO-1 is a promising cancer vaccine target.
T2 120-184 Sentence denotes The tumor antigen NY-ESO-1 is a promising cancer vaccine target.
TextSentencer_T3 185-341 Sentence denotes We describe here a novel HLA-B7-restricted NY-ESO-1 epitope, encompassing amino acids 60-72 (APRGPHGGAASGL), which is naturally presented by melanoma cells.
T3 185-341 Sentence denotes We describe here a novel HLA-B7-restricted NY-ESO-1 epitope, encompassing amino acids 60-72 (APRGPHGGAASGL), which is naturally presented by melanoma cells.
TextSentencer_T4 342-426 Sentence denotes The tumor epitope bound to HLA-B7 by bulging outward from the peptide-binding cleft.
T4 342-426 Sentence denotes The tumor epitope bound to HLA-B7 by bulging outward from the peptide-binding cleft.
TextSentencer_T5 427-648 Sentence denotes This bulged epitope was not an impediment to T-cell recognition, however, because four of six HLA-B7(+) melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX vaccine generated a potent T-cell response to this determinant.
T5 427-648 Sentence denotes This bulged epitope was not an impediment to T-cell recognition, however, because four of six HLA-B7(+) melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX vaccine generated a potent T-cell response to this determinant.
TextSentencer_T6 649-872 Sentence denotes Moreover, the response to this epitope was immunodominant in three of these patients and, unlike the T-cell responses to bulged HLA class I viral epitopes, the responding T cells possessed a remarkably broad TCR repertoire.
T6 649-872 Sentence denotes Moreover, the response to this epitope was immunodominant in three of these patients and, unlike the T-cell responses to bulged HLA class I viral epitopes, the responding T cells possessed a remarkably broad TCR repertoire.
TextSentencer_T7 873-1162 Sentence denotes Interestingly, HLA-B7(+) melanoma patients who did not receive the NY-ESO-1 ISCOMATRIX vaccine rarely generated a spontaneous T-cell response to this cryptic epitope, suggesting a lack of priming of such T cells in the natural anti-NY-ESO-1 response, which may be corrected by vaccination.
T7 873-1162 Sentence denotes Interestingly, HLA-B7(+) melanoma patients who did not receive the NY-ESO-1 ISCOMATRIX vaccine rarely generated a spontaneous T-cell response to this cryptic epitope, suggesting a lack of priming of such T cells in the natural anti-NY-ESO-1 response, which may be corrected by vaccination.
TextSentencer_T8 1163-1289 Sentence denotes Together, our results reveal several surprising aspects of antitumor immunity and have implications for cancer vaccine design.
T8 1163-1289 Sentence denotes Together, our results reveal several surprising aspects of antitumor immunity and have implications for cancer vaccine design.