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PubMed:19146938 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-161 Sentence denotes Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.
T1 0-161 Sentence denotes Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.
TextSentencer_T2 162-180 Sentence denotes AIM OF THIS STUDY:
T2 162-180 Sentence denotes AIM OF THIS STUDY:
TextSentencer_T3 181-440 Sentence denotes Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.
T3 181-440 Sentence denotes Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.
TextSentencer_T4 441-463 Sentence denotes MATERIALS AND METHODS:
T4 441-463 Sentence denotes MATERIALS AND METHODS:
TextSentencer_T5 464-572 Sentence denotes Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old).
T5 464-572 Sentence denotes Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old).
TextSentencer_T6 573-719 Sentence denotes The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.
T6 573-719 Sentence denotes The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.
TextSentencer_T7 720-728 Sentence denotes RESULTS:
T7 720-728 Sentence denotes RESULTS:
TextSentencer_T8 729-876 Sentence denotes Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test.
T8 729-876 Sentence denotes Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test.
TextSentencer_T9 877-1061 Sentence denotes In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice.
T9 877-1061 Sentence denotes In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice.
TextSentencer_T10 1062-1201 Sentence denotes In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.
T10 1062-1201 Sentence denotes In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.
TextSentencer_T11 1202-1213 Sentence denotes CONCLUSION:
T11 1202-1213 Sentence denotes CONCLUSION:
TextSentencer_T12 1214-1455 Sentence denotes These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice.
T12 1214-1455 Sentence denotes These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice.