| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-121 |
Sentence |
denotes |
Functional characterization of the Bombyx mori fatty acid transport protein (BmFATP) within the silkmoth pheromone gland. |
| T2 |
122-280 |
Sentence |
denotes |
Fatty acid transport protein (FATP) is an evolutionarily conserved membrane-bound protein that facilitates the uptake of extracellular long chain fatty acids. |
| T3 |
281-478 |
Sentence |
denotes |
In humans and mice, six FATP isoforms have been identified and their tissue-specific distributions suggest that each plays a discrete role in lipid metabolism in association with fatty acid uptake. |
| T4 |
479-599 |
Sentence |
denotes |
While the presence of FATP homologs in insects has been demonstrated, their functional role remains to be characterized. |
| T5 |
600-778 |
Sentence |
denotes |
Pheromonogenesis is defined as the dynamic period in which all machinery required for sex pheromone biosynthesis is generated and organized within the pheromone gland (PG) cells. |
| T6 |
779-962 |
Sentence |
denotes |
By exploiting this unique system in the PG of the silkmoth, Bombyx mori, we found that BmFATP is predominantly expressed in the PG and undergoes up-regulation 1 day prior to eclosion. |
| T7 |
963-1148 |
Sentence |
denotes |
Before eclosion, B. mori PG cells accumulate cytoplasmic lipid droplets (LDs), which play a role in storing the pheromone (bombykol) precursor fatty acid in the form of triacylglycerol. |
| T8 |
1149-1348 |
Sentence |
denotes |
RNAi-mediated gene silencing of BmFATP in vivo significantly suppressed LD accumulation by preventing the synthesis of triacylglycerols and resulted in a significant reduction in bombykol production. |
| T9 |
1349-1837 |
Sentence |
denotes |
These results, in conjunction with the findings that BmFATP stimulates the uptake of extracellular long-chain fatty acids and BmFATP knockdown reduces cellular long-chain acyl-CoA synthetase activity, suggest that BmFATP plays an essential role in bombykol biosynthesis by stimulating both LD accumulation and triacylglycerol synthesis via a process called vectorial acylation that couples the uptake of extracellular fatty acids with activation to CoA thioesters during pheromonogenesis. |
