| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-95 |
Sentence |
denotes |
Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. |
| T1 |
0-95 |
Sentence |
denotes |
Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. |
| TextSentencer_T2 |
96-107 |
Sentence |
denotes |
BACKGROUND: |
| T2 |
96-107 |
Sentence |
denotes |
BACKGROUND: |
| TextSentencer_T3 |
108-218 |
Sentence |
denotes |
Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. |
| T3 |
108-218 |
Sentence |
denotes |
Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. |
| TextSentencer_T4 |
219-354 |
Sentence |
denotes |
Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. |
| T4 |
219-354 |
Sentence |
denotes |
Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. |
| TextSentencer_T5 |
355-578 |
Sentence |
denotes |
The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk. |
| T5 |
355-578 |
Sentence |
denotes |
The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk. |
| TextSentencer_T6 |
579-587 |
Sentence |
denotes |
METHODS: |
| T6 |
579-587 |
Sentence |
denotes |
METHODS: |
| TextSentencer_T7 |
588-910 |
Sentence |
denotes |
A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area. |
| T7 |
588-910 |
Sentence |
denotes |
A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area. |
| TextSentencer_T8 |
911-919 |
Sentence |
denotes |
RESULTS: |
| T8 |
911-919 |
Sentence |
denotes |
RESULTS: |
| TextSentencer_T9 |
920-1094 |
Sentence |
denotes |
Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). |
| T9 |
920-1094 |
Sentence |
denotes |
Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). |
| TextSentencer_T10 |
1095-1223 |
Sentence |
denotes |
A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. |
| T10 |
1095-1223 |
Sentence |
denotes |
A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. |
| TextSentencer_T11 |
1224-1309 |
Sentence |
denotes |
No epistatic effect was found for the combination of different polymorphisms studied. |
| T11 |
1224-1309 |
Sentence |
denotes |
No epistatic effect was found for the combination of different polymorphisms studied. |
| TextSentencer_T12 |
1310-1414 |
Sentence |
denotes |
Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms. |
| T12 |
1310-1414 |
Sentence |
denotes |
Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms. |
| TextSentencer_T13 |
1415-1426 |
Sentence |
denotes |
CONCLUSION: |
| T13 |
1415-1426 |
Sentence |
denotes |
CONCLUSION: |
| TextSentencer_T14 |
1427-1629 |
Sentence |
denotes |
Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development. |
| T14 |
1427-1629 |
Sentence |
denotes |
Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development. |
