> top > projects > sentences > docs > PubMed:1906877 > annotations
sentences Home  

PubMed:1906877 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-70 Sentence denotes Molecular characterization of a unique von Willebrand disease variant.
T1 0-70 Sentence denotes Molecular characterization of a unique von Willebrand disease variant.
TextSentencer_T2 71-144 Sentence denotes A novel mutation affecting von Willebrand factor/factor VIII interaction.
T2 71-144 Sentence denotes A novel mutation affecting von Willebrand factor/factor VIII interaction.
TextSentencer_T3 145-361 Sentence denotes von Willebrand factor (vWF) plays a central role in blood coagulation, mediating the adhesion of the initial platelet plug to the subendothelium, and serving as the carrier for factor VIII (FVIII) in the circulation.
T3 145-361 Sentence denotes von Willebrand factor (vWF) plays a central role in blood coagulation, mediating the adhesion of the initial platelet plug to the subendothelium, and serving as the carrier for factor VIII (FVIII) in the circulation.
TextSentencer_T4 362-625 Sentence denotes In previous studies, we have mapped the epitope for an anti-vWF monoclonal antibody which inhibits the interaction between FVIII and vWF to a region spanning Thr78 to Thr96 of the mature protein (Bahou, W.F., Ginsburg, D., Sikkink, R., Litwiller, R., and Fass, D.
T4 362-625 Sentence denotes In previous studies, we have mapped the epitope for an anti-vWF monoclonal antibody which inhibits the interaction between FVIII and vWF to a region spanning Thr78 to Thr96 of the mature protein (Bahou, W.F., Ginsburg, D., Sikkink, R., Litwiller, R., and Fass, D.
TextSentencer_T5 626-638 Sentence denotes N. (1989) J.
T5 626-638 Sentence denotes N. (1989) J.
TextSentencer_T6 639-644 Sentence denotes Clin.
T6 639-644 Sentence denotes Clin.
TextSentencer_T7 645-652 Sentence denotes Invest.
T7 645-652 Sentence denotes Invest.
TextSentencer_T8 653-664 Sentence denotes 84, 56-61).
T8 653-664 Sentence denotes 84, 56-61).
TextSentencer_T9 665-778 Sentence denotes We now report the identification of a mutation within this region of vWF that results in decreased FVIII binding.
T9 665-778 Sentence denotes We now report the identification of a mutation within this region of vWF that results in decreased FVIII binding.
TextSentencer_T10 779-1038 Sentence denotes Sequence analysis of polymerase chain reaction amplified platelet vWF mRNA from a von Willebrand disease (vWD) patient with a disproportionately low FVIII level identified a single nucleotide substitution (G----A), resulting in the conversion of Arg91----Gln.
T10 779-1038 Sentence denotes Sequence analysis of polymerase chain reaction amplified platelet vWF mRNA from a von Willebrand disease (vWD) patient with a disproportionately low FVIII level identified a single nucleotide substitution (G----A), resulting in the conversion of Arg91----Gln.
TextSentencer_T11 1039-1221 Sentence denotes Recombinant vWF carrying this substitution showed decreased binding to FVIII compared with wild-type vWF or vWF carrying a polymorphic substitution in the same region (Arg89----Gln).
T11 1039-1221 Sentence denotes Recombinant vWF carrying this substitution showed decreased binding to FVIII compared with wild-type vWF or vWF carrying a polymorphic substitution in the same region (Arg89----Gln).
TextSentencer_T12 1222-1413 Sentence denotes These observations suggest a critical role for Arg91 in the interaction of vWF with FVIII and identify the molecular mechanism for a variant of vWD associated with unusually low FVIII levels.
T12 1222-1413 Sentence denotes These observations suggest a critical role for Arg91 in the interaction of vWF with FVIII and identify the molecular mechanism for a variant of vWD associated with unusually low FVIII levels.