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PubMed:18982394 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
T1 0-138 Sentence denotes Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
TextSentencer_T2 139-354 Sentence denotes The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN).
T2 139-354 Sentence denotes The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN).
TextSentencer_T3 355-641 Sentence denotes Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness.
T3 355-641 Sentence denotes Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness.
TextSentencer_T4 642-694 Sentence denotes SLNs were examined by serial-section histopathology.
T4 642-694 Sentence denotes SLNs were examined by serial-section histopathology.
TextSentencer_T5 695-815 Sentence denotes A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T.
T5 695-815 Sentence denotes A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T.
TextSentencer_T6 816-929 Sentence denotes In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis.
T6 816-929 Sentence denotes In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis.
TextSentencer_T7 930-1013 Sentence denotes Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences.
T7 930-1013 Sentence denotes Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences.
TextSentencer_T8 1014-1066 Sentence denotes A total of 370 lymph nodes were analyzed by qRT-PCR.
T8 1014-1066 Sentence denotes A total of 370 lymph nodes were analyzed by qRT-PCR.
TextSentencer_T9 1067-1167 Sentence denotes No association was found between quantitative expression level of any marker and disease recurrence.
T9 1067-1167 Sentence denotes No association was found between quantitative expression level of any marker and disease recurrence.
TextSentencer_T10 1168-1349 Sentence denotes Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes.
T10 1168-1349 Sentence denotes Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes.
TextSentencer_T11 1350-1458 Sentence denotes No associations with recurrence were found regardless of the transcripts amplified by different primer sets.
T11 1350-1458 Sentence denotes No associations with recurrence were found regardless of the transcripts amplified by different primer sets.
TextSentencer_T12 1459-1587 Sentence denotes PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis.
T12 1459-1587 Sentence denotes PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis.
TextSentencer_T13 1588-1719 Sentence denotes We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence.
T13 1588-1719 Sentence denotes We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence.
TextSentencer_T14 1720-1851 Sentence denotes Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.
T14 1720-1851 Sentence denotes Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.