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PubMed:18929508 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-61 Sentence denotes TDP-43: an emerging new player in neurodegenerative diseases.
T1 0-61 Sentence denotes TDP-43: an emerging new player in neurodegenerative diseases.
TextSentencer_T2 62-222 Sentence denotes Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing.
T2 62-222 Sentence denotes Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing.
TextSentencer_T3 223-625 Sentence denotes Since 2006, when the protein was reported to be present in inclusions in the neurons and/or glial cells of a range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive, tau- and alpha-synuclein-negative inclusions (FTLD-U) and Alzheimer's disease (AD), many reports on the medical aspects of TDP-43 have been published.
T3 223-625 Sentence denotes Since 2006, when the protein was reported to be present in inclusions in the neurons and/or glial cells of a range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive, tau- and alpha-synuclein-negative inclusions (FTLD-U) and Alzheimer's disease (AD), many reports on the medical aspects of TDP-43 have been published.
TextSentencer_T4 626-751 Sentence denotes Here, we summarize the current literature on TDP-43, focusing on recent studies that provide clues to the function of TDP-43.
T4 626-751 Sentence denotes Here, we summarize the current literature on TDP-43, focusing on recent studies that provide clues to the function of TDP-43.
TextSentencer_T5 752-1039 Sentence denotes Using this information and database analysis, we also suggest a molecular and cellular model for possible events in normal and diseased neurons in relation to the emerging importance of the function and dysfunction of this protein as a target for basic as well as translational research.
T5 752-1039 Sentence denotes Using this information and database analysis, we also suggest a molecular and cellular model for possible events in normal and diseased neurons in relation to the emerging importance of the function and dysfunction of this protein as a target for basic as well as translational research.