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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-47 Sentence denotes Leptin signaling in breast cancer: an overview.
T1 0-47 Sentence denotes Leptin signaling in breast cancer: an overview.
TextSentencer_T2 48-200 Sentence denotes The adipocyte-derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa-f) have been identified up to now.
T2 48-200 Sentence denotes The adipocyte-derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa-f) have been identified up to now.
TextSentencer_T3 201-352 Sentence denotes Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 signaling pathways.
T3 201-352 Sentence denotes Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 signaling pathways.
TextSentencer_T4 353-583 Sentence denotes Since the circulating levels of leptin are elevated in obese individuals, and excess body weight has been shown to increase breast cancer risk in postmenopausal women, several studies addressed the role of leptin in breast cancer.
T4 353-583 Sentence denotes Since the circulating levels of leptin are elevated in obese individuals, and excess body weight has been shown to increase breast cancer risk in postmenopausal women, several studies addressed the role of leptin in breast cancer.
TextSentencer_T5 584-720 Sentence denotes Expression of leptin and its receptors has been demonstrated to occur in breast cancer cell lines and in human primary breast carcinoma.
T5 584-720 Sentence denotes Expression of leptin and its receptors has been demonstrated to occur in breast cancer cell lines and in human primary breast carcinoma.
TextSentencer_T6 721-948 Sentence denotes Leptin is able to induce the growth of breast cancer cells through activation of the Jak/STAT3, ERK1/2, and/or PI3K pathways, and can mediate angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF).
T6 721-948 Sentence denotes Leptin is able to induce the growth of breast cancer cells through activation of the Jak/STAT3, ERK1/2, and/or PI3K pathways, and can mediate angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF).
TextSentencer_T7 949-1199 Sentence denotes In addition, leptin induces transactivation of ErbB-2, and interacts in triple negative breast cancer cells with insulin like growth factor-1 (IGF-1) to transactivate the epidermal growth factor receptor (EGFR), thus promoting invasion and migration.
T7 949-1199 Sentence denotes In addition, leptin induces transactivation of ErbB-2, and interacts in triple negative breast cancer cells with insulin like growth factor-1 (IGF-1) to transactivate the epidermal growth factor receptor (EGFR), thus promoting invasion and migration.
TextSentencer_T8 1200-1453 Sentence denotes Leptin can also affect the growth of estrogen receptor (ER)-positive breast cancer cells, by stimulating aromatase expression and thereby increasing estrogen levels through the aromatization of androgens, and by inducing MAPK-dependent activation of ER.
T8 1200-1453 Sentence denotes Leptin can also affect the growth of estrogen receptor (ER)-positive breast cancer cells, by stimulating aromatase expression and thereby increasing estrogen levels through the aromatization of androgens, and by inducing MAPK-dependent activation of ER.
TextSentencer_T9 1454-1681 Sentence denotes Taken together, these findings suggest that the leptin system might play an important role in breast cancer pathogenesis and progression, and that it might represent a novel target for therapeutic intervention in breast cancer.
T9 1454-1681 Sentence denotes Taken together, these findings suggest that the leptin system might play an important role in breast cancer pathogenesis and progression, and that it might represent a novel target for therapeutic intervention in breast cancer.