| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-103 |
Sentence |
denotes |
Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. |
| T1 |
0-103 |
Sentence |
denotes |
Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. |
| TextSentencer_T2 |
104-234 |
Sentence |
denotes |
There is a correlation between the multidrug-resistance (MDR) of cancer cells and their enhanced invasive or metastatic potential. |
| T2 |
104-234 |
Sentence |
denotes |
There is a correlation between the multidrug-resistance (MDR) of cancer cells and their enhanced invasive or metastatic potential. |
| TextSentencer_T3 |
235-477 |
Sentence |
denotes |
We studied the expression of CD147, a plasma membrane glycoprotein that plays a key role in tumor metastasis by stimulating the production of matrix metalloproteinases (MMPs), in sensitive human oral squamous KB and MDR derivative KB/V cells. |
| T3 |
235-477 |
Sentence |
denotes |
We studied the expression of CD147, a plasma membrane glycoprotein that plays a key role in tumor metastasis by stimulating the production of matrix metalloproteinases (MMPs), in sensitive human oral squamous KB and MDR derivative KB/V cells. |
| TextSentencer_T4 |
478-634 |
Sentence |
denotes |
Reverse transcription-PCR and flow cytometric analysis revealed that KB/V cells expressed CD147 at significantly higher levels than their parental KB cells. |
| T4 |
478-634 |
Sentence |
denotes |
Reverse transcription-PCR and flow cytometric analysis revealed that KB/V cells expressed CD147 at significantly higher levels than their parental KB cells. |
| TextSentencer_T5 |
635-743 |
Sentence |
denotes |
Using stable RNA interference, we succeeded in establishing a CD147 knock-down KB/V cell line (KB/VsiCD147). |
| T5 |
635-743 |
Sentence |
denotes |
Using stable RNA interference, we succeeded in establishing a CD147 knock-down KB/V cell line (KB/VsiCD147). |
| TextSentencer_T6 |
744-917 |
Sentence |
denotes |
MTT colorimetric assay showed an increase in the chemosensitivity to vincristine (VCR), all transretinoic acid (ATRA), taxol, and 5-fluorouracil (5-Fu) of KB/VsiCD147 cells. |
| T6 |
744-917 |
Sentence |
denotes |
MTT colorimetric assay showed an increase in the chemosensitivity to vincristine (VCR), all transretinoic acid (ATRA), taxol, and 5-fluorouracil (5-Fu) of KB/VsiCD147 cells. |
| TextSentencer_T7 |
918-1021 |
Sentence |
denotes |
Proteome analysis of KB, KB/V, and KB/VsiCD147 cell lines identified 21 differently expressed proteins. |
| T7 |
918-1021 |
Sentence |
denotes |
Proteome analysis of KB, KB/V, and KB/VsiCD147 cell lines identified 21 differently expressed proteins. |
| TextSentencer_T8 |
1022-1142 |
Sentence |
denotes |
The enhanced expression of representative active proteins, GRP75 and CyPA, was confirmed by Western blotting and RT-PCR. |
| T8 |
1022-1142 |
Sentence |
denotes |
The enhanced expression of representative active proteins, GRP75 and CyPA, was confirmed by Western blotting and RT-PCR. |
| TextSentencer_T9 |
1143-1297 |
Sentence |
denotes |
In addition, pretreatment of KB/V cells with a CyPA-binding immunosuppressive drug, cyclosporine A (CsA), enhanced their chemosensitivity to VCR and 5-Fu. |
| T9 |
1143-1297 |
Sentence |
denotes |
In addition, pretreatment of KB/V cells with a CyPA-binding immunosuppressive drug, cyclosporine A (CsA), enhanced their chemosensitivity to VCR and 5-Fu. |
| TextSentencer_T10 |
1298-1411 |
Sentence |
denotes |
We document an abundance of molecules that interact with CD147 in the MDR of human oral squamous carcinoma cells. |
| T10 |
1298-1411 |
Sentence |
denotes |
We document an abundance of molecules that interact with CD147 in the MDR of human oral squamous carcinoma cells. |
| TextSentencer_T11 |
1412-1494 |
Sentence |
denotes |
Additional studies are needed to investigate these novel target proteins of CD147. |
| T11 |
1412-1494 |
Sentence |
denotes |
Additional studies are needed to investigate these novel target proteins of CD147. |