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PubMed:18796645 JSONTXT 69 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.
T1 0-102 Sentence denotes Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.
T1 0-102 Sentence denotes Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.
TextSentencer_T2 103-290 Sentence denotes Galectin-1 (Gal-1), a member of the beta-galactoside-binding animal lectin family, has a wide range of biological activities, which makes it an attractive target for medical applications.
T2 103-290 Sentence denotes Galectin-1 (Gal-1), a member of the beta-galactoside-binding animal lectin family, has a wide range of biological activities, which makes it an attractive target for medical applications.
T2 103-290 Sentence denotes Galectin-1 (Gal-1), a member of the beta-galactoside-binding animal lectin family, has a wide range of biological activities, which makes it an attractive target for medical applications.
TextSentencer_T3 291-418 Sentence denotes Unlike other galectins, Gal-1 is susceptible to oxidation at cysteine residues, which is troublesome for in vitro/vivo studies.
T3 291-418 Sentence denotes Unlike other galectins, Gal-1 is susceptible to oxidation at cysteine residues, which is troublesome for in vitro/vivo studies.
T3 291-418 Sentence denotes Unlike other galectins, Gal-1 is susceptible to oxidation at cysteine residues, which is troublesome for in vitro/vivo studies.
TextSentencer_T4 419-558 Sentence denotes To overcome this problem, we prepared a cysteine-less mutant of Gal-1 (CSGal-1) by substituting all cysteine residues with serine residues.
T4 419-558 Sentence denotes To overcome this problem, we prepared a cysteine-less mutant of Gal-1 (CSGal-1) by substituting all cysteine residues with serine residues.
T4 419-558 Sentence denotes To overcome this problem, we prepared a cysteine-less mutant of Gal-1 (CSGal-1) by substituting all cysteine residues with serine residues.
TextSentencer_T5 559-871 Sentence denotes In the case of wild-type Gal-1, the formation of covalent dimers/oligomers was evident after 10 days of storage in the absence of a reducing agent with a concomitant decrease in hemagglutination activity, while CSGal-1 did not form multimers and retained full hemagglutination activity after 400 days of storage.
T5 559-871 Sentence denotes In the case of wild-type Gal-1, the formation of covalent dimers/oligomers was evident after 10 days of storage in the absence of a reducing agent with a concomitant decrease in hemagglutination activity, while CSGal-1 did not form multimers and retained full hemagglutination activity after 400 days of storage.
T5 559-871 Sentence denotes In the case of wild-type Gal-1, the formation of covalent dimers/oligomers was evident after 10 days of storage in the absence of a reducing agent with a concomitant decrease in hemagglutination activity, while CSGal-1 did not form multimers and retained full hemagglutination activity after 400 days of storage.
TextSentencer_T6 872-1026 Sentence denotes Frontal affinity chromatography showed that the sugar-binding specificity and affinity of Gal-1 for model glycans were barely affected by the mutagenesis.
T6 872-1026 Sentence denotes Frontal affinity chromatography showed that the sugar-binding specificity and affinity of Gal-1 for model glycans were barely affected by the mutagenesis.
T6 872-1026 Sentence denotes Frontal affinity chromatography showed that the sugar-binding specificity and affinity of Gal-1 for model glycans were barely affected by the mutagenesis.
TextSentencer_T7 1027-1154 Sentence denotes Gal-1 is known to induce cell signaling leading to an increase in the intracytoplasmic calcium concentration and to cell death.
T7 1027-1154 Sentence denotes Gal-1 is known to induce cell signaling leading to an increase in the intracytoplasmic calcium concentration and to cell death.
T7 1027-1154 Sentence denotes Gal-1 is known to induce cell signaling leading to an increase in the intracytoplasmic calcium concentration and to cell death.
TextSentencer_T8 1155-1310 Sentence denotes CSGal-1 is also capable of inducing calcium flux and growth inhibition in Jurkat cells, which are comparable to or more potent than those induced by Gal-1.
T8 1155-1310 Sentence denotes CSGal-1 is also capable of inducing calcium flux and growth inhibition in Jurkat cells, which are comparable to or more potent than those induced by Gal-1.
T8 1155-1310 Sentence denotes CSGal-1 is also capable of inducing calcium flux and growth inhibition in Jurkat cells, which are comparable to or more potent than those induced by Gal-1.
TextSentencer_T9 1311-1382 Sentence denotes The X-ray structure of the CSGal-1/lactose complex has been determined.
T9 1311-1382 Sentence denotes The X-ray structure of the CSGal-1/lactose complex has been determined.
T9 1311-1382 Sentence denotes The X-ray structure of the CSGal-1/lactose complex has been determined.
TextSentencer_T10 1383-1594 Sentence denotes The structure of CSGal-1 is almost identical to that of wild-type human Gal-1, showing that the amino acid substitutions do not affect the overall structure or carbohydrate-binding site structure of the protein.
T10 1383-1594 Sentence denotes The structure of CSGal-1 is almost identical to that of wild-type human Gal-1, showing that the amino acid substitutions do not affect the overall structure or carbohydrate-binding site structure of the protein.
T10 1383-1594 Sentence denotes The structure of CSGal-1 is almost identical to that of wild-type human Gal-1, showing that the amino acid substitutions do not affect the overall structure or carbohydrate-binding site structure of the protein.
TextSentencer_T11 1595-1674 Sentence denotes These results indicate that CSGal-1 can serve as a stable substitute for Gal-1.
T11 1595-1674 Sentence denotes These results indicate that CSGal-1 can serve as a stable substitute for Gal-1.
T11 1595-1674 Sentence denotes These results indicate that CSGal-1 can serve as a stable substitute for Gal-1.