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PubMed:18757779 JSONTXT 67 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
TextSentencer_T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
TextSentencer_T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
TextSentencer_T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
TextSentencer_T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
TextSentencer_T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
TextSentencer_T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
TextSentencer_T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
TextSentencer_T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
TextSentencer_T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
TextSentencer_T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.
T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.
T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.