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PubMed:18702176 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-167 Sentence denotes Minimal disease monitoring by QRT-PCR: guidelines for identification and systematic validation of molecular markers prior to evaluation in prospective clinical trials.
T1 0-167 Sentence denotes Minimal disease monitoring by QRT-PCR: guidelines for identification and systematic validation of molecular markers prior to evaluation in prospective clinical trials.
TextSentencer_T2 168-347 Sentence denotes Real-time RT-PCR (QRT-PCR) is a sensitive method for the detection of minimal disease (MD) and may improve monitoring of disease status and stratification of patients for therapy.
T2 168-347 Sentence denotes Real-time RT-PCR (QRT-PCR) is a sensitive method for the detection of minimal disease (MD) and may improve monitoring of disease status and stratification of patients for therapy.
TextSentencer_T3 348-495 Sentence denotes Where tumour-specific mRNAs have not been identified, the selection of which target(s) is(are) optimal for the detection of MD remains a challenge.
T3 348-495 Sentence denotes Where tumour-specific mRNAs have not been identified, the selection of which target(s) is(are) optimal for the detection of MD remains a challenge.
TextSentencer_T4 496-648 Sentence denotes This reflects the heterogeneity of tumour cells, the stability of mRNAs and low-level of transcription in cells of the normal haemopoietic compartments.
T4 496-648 Sentence denotes This reflects the heterogeneity of tumour cells, the stability of mRNAs and low-level of transcription in cells of the normal haemopoietic compartments.
TextSentencer_T5 649-871 Sentence denotes The aim of this study was to establish for the first time guidelines for the systematic prioritization of potential markers of MD detected by QRT-PCR prior to evaluation in multicentre prospective clinical outcome studies.
T5 649-871 Sentence denotes The aim of this study was to establish for the first time guidelines for the systematic prioritization of potential markers of MD detected by QRT-PCR prior to evaluation in multicentre prospective clinical outcome studies.
TextSentencer_T6 872-1104 Sentence denotes We combined microarray analysis, ESTs gene expression profiles, improved probe-sets sequence annotation, and previously described standard operating procedures for QRT-PCR analysis to identify and prioritize potential markers of MD.
T6 872-1104 Sentence denotes We combined microarray analysis, ESTs gene expression profiles, improved probe-sets sequence annotation, and previously described standard operating procedures for QRT-PCR analysis to identify and prioritize potential markers of MD.
TextSentencer_T7 1105-1244 Sentence denotes Using this methodology, we identified 49 potential markers of MD in neuroblastoma (NB), of which 11 were associated with neuronal function.
T7 1105-1244 Sentence denotes Using this methodology, we identified 49 potential markers of MD in neuroblastoma (NB), of which 11 were associated with neuronal function.
TextSentencer_T8 1245-1365 Sentence denotes We found that, in addition to TH, Phox2B and DCX mRNA may be useful targets for the detection of MD in children with NB.
T8 1245-1365 Sentence denotes We found that, in addition to TH, Phox2B and DCX mRNA may be useful targets for the detection of MD in children with NB.
TextSentencer_T9 1366-1541 Sentence denotes This same strategy could be exploited to select MD markers of other solid tumours from the large number of potential targets identified by microarray gene expression profiles.
T9 1366-1541 Sentence denotes This same strategy could be exploited to select MD markers of other solid tumours from the large number of potential targets identified by microarray gene expression profiles.