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PubMed:18611854 JSONTXT 42 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
T2 109-233 Sentence denotes The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier to cell and neurite motility.
T3 234-377 Sentence denotes Nonneural tumors that metastasize to the central nervous system almost never infiltrate it and instead displace the neural tissue as they grow.
T4 378-479 Sentence denotes In contrast, invasive gliomas disrupt the extracellular matrix and disperse within the neural tissue.
T5 480-656 Sentence denotes A major inhibitory component of the neural matrix is the lectican family of chondroitin sulfate proteoglycans, of which brevican is the most abundant member in the adult brain.
T6 657-773 Sentence denotes Interestingly, brevican is also highly up-regulated in gliomas and promotes glioma dispersion by unknown mechanisms.
T7 774-894 Sentence denotes Here we show that brevican secreted by glioma cells enhances cell adhesion and motility only after proteolytic cleavage.
T8 895-1142 Sentence denotes At the molecular level, brevican promotes epidermal growth factor receptor activation, increases the expression of cell adhesion molecules, and promotes the secretion of fibronectin and accumulation of fibronectin microfibrils on the cell surface.
T9 1143-1311 Sentence denotes Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
T10 1312-1490 Sentence denotes Taken together, our results provide the first evidence of the cellular and molecular mechanisms that may underlie the motility-promoting role of brevican in primary brain tumors.
T11 1491-1612 Sentence denotes In addition, these results underscore the important functional implications of brevican processing in glioma progression.