| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-83 |
Sentence |
denotes |
Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. |
| T1 |
0-83 |
Sentence |
denotes |
Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. |
| T1 |
0-83 |
Sentence |
denotes |
Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. |
| TextSentencer_T2 |
84-439 |
Sentence |
denotes |
Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL. |
| T2 |
84-439 |
Sentence |
denotes |
Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL. |
| T2 |
84-439 |
Sentence |
denotes |
Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL. |
| TextSentencer_T3 |
440-445 |
Sentence |
denotes |
2004. |
| T3 |
440-445 |
Sentence |
denotes |
2004. |
| T3 |
440-445 |
Sentence |
denotes |
2004. |
| TextSentencer_T4 |
446-510 |
Sentence |
denotes |
Polysaccharide processing and presentation by the MHCII pathway. |
| T4 |
446-510 |
Sentence |
denotes |
Polysaccharide processing and presentation by the MHCII pathway. |
| T4 |
446-510 |
Sentence |
denotes |
Polysaccharide processing and presentation by the MHCII pathway. |
| TextSentencer_T5 |
511-516 |
Sentence |
denotes |
Cell. |
| T5 |
511-516 |
Sentence |
denotes |
Cell. |
| T5 |
511-530 |
Sentence |
denotes |
Cell. 117:677-687). |
| TextSentencer_T6 |
517-530 |
Sentence |
denotes |
117:677-687). |
| T6 |
517-530 |
Sentence |
denotes |
117:677-687). |
| TextSentencer_T7 |
531-636 |
Sentence |
denotes |
A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL. |
| T6 |
531-636 |
Sentence |
denotes |
A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL. |
| T7 |
531-636 |
Sentence |
denotes |
A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL. |
| TextSentencer_T8 |
637-642 |
Sentence |
denotes |
2000. |
| T7 |
637-642 |
Sentence |
denotes |
2000. |
| T8 |
637-642 |
Sentence |
denotes |
2000. |
| TextSentencer_T9 |
643-730 |
Sentence |
denotes |
Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis. |
| T8 |
643-730 |
Sentence |
denotes |
Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis. |
| T9 |
643-730 |
Sentence |
denotes |
Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis. |
| TextSentencer_T10 |
731-754 |
Sentence |
denotes |
Proc Natl Acad Sci USA. |
| T9 |
731-754 |
Sentence |
denotes |
Proc Natl Acad Sci USA. |
| T10 |
731-754 |
Sentence |
denotes |
Proc Natl Acad Sci USA. |
| TextSentencer_T11 |
755-810 |
Sentence |
denotes |
97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY. |
| T10 |
755-810 |
Sentence |
denotes |
97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY. |
| T11 |
755-810 |
Sentence |
denotes |
97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY. |
| TextSentencer_T12 |
811-816 |
Sentence |
denotes |
2002. |
| T11 |
811-816 |
Sentence |
denotes |
2002. |
| T12 |
811-816 |
Sentence |
denotes |
2002. |
| TextSentencer_T13 |
817-925 |
Sentence |
denotes |
A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides. |
| T12 |
817-925 |
Sentence |
denotes |
A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides. |
| T13 |
817-925 |
Sentence |
denotes |
A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides. |
| TextSentencer_T14 |
926-939 |
Sentence |
denotes |
Biochemistry. |
| T14 |
926-939 |
Sentence |
denotes |
Biochemistry. |
| T13 |
926-1062 |
Sentence |
denotes |
Biochemistry. 41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL. |
| TextSentencer_T15 |
940-1062 |
Sentence |
denotes |
41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL. |
| T15 |
940-1062 |
Sentence |
denotes |
41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL. |
| TextSentencer_T16 |
1063-1068 |
Sentence |
denotes |
1993. |
| T14 |
1063-1068 |
Sentence |
denotes |
1993. |
| T16 |
1063-1068 |
Sentence |
denotes |
1993. |
| TextSentencer_T17 |
1069-1146 |
Sentence |
denotes |
Structural features of polysaccharides that induce intra-abdominal abscesses. |
| T15 |
1069-1146 |
Sentence |
denotes |
Structural features of polysaccharides that induce intra-abdominal abscesses. |
| T17 |
1069-1146 |
Sentence |
denotes |
Structural features of polysaccharides that induce intra-abdominal abscesses. |
| TextSentencer_T18 |
1147-1155 |
Sentence |
denotes |
Science. |
| T18 |
1147-1155 |
Sentence |
denotes |
Science. |
| T16 |
1147-1262 |
Sentence |
denotes |
Science. 262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA. |
| TextSentencer_T19 |
1156-1262 |
Sentence |
denotes |
262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA. |
| T19 |
1156-1262 |
Sentence |
denotes |
262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA. |
| TextSentencer_T20 |
1263-1268 |
Sentence |
denotes |
2007. |
| T17 |
1263-1268 |
Sentence |
denotes |
2007. |
| T20 |
1263-1268 |
Sentence |
denotes |
2007. |
| TextSentencer_T21 |
1269-1375 |
Sentence |
denotes |
Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism. |
| T18 |
1269-1375 |
Sentence |
denotes |
Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism. |
| T21 |
1269-1375 |
Sentence |
denotes |
Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism. |
| TextSentencer_T22 |
1376-1389 |
Sentence |
denotes |
Glycobiology. |
| T22 |
1376-1389 |
Sentence |
denotes |
Glycobiology. |
| T19 |
1376-1466 |
Sentence |
denotes |
Glycobiology. 17:46-55), suggesting a strong carbohydrate structure-function relationship. |
| TextSentencer_T23 |
1390-1466 |
Sentence |
denotes |
17:46-55), suggesting a strong carbohydrate structure-function relationship. |
| T23 |
1390-1466 |
Sentence |
denotes |
17:46-55), suggesting a strong carbohydrate structure-function relationship. |
| TextSentencer_T24 |
1467-1647 |
Sentence |
denotes |
In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation. |
| T20 |
1467-1647 |
Sentence |
denotes |
In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation. |
| T24 |
1467-1647 |
Sentence |
denotes |
In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation. |
| TextSentencer_T25 |
1648-1788 |
Sentence |
denotes |
Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity. |
| T21 |
1648-1788 |
Sentence |
denotes |
Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity. |
| T25 |
1648-1788 |
Sentence |
denotes |
Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity. |
| TextSentencer_T26 |
1789-1994 |
Sentence |
denotes |
The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation. |
| T22 |
1789-1994 |
Sentence |
denotes |
The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation. |
| T26 |
1789-1994 |
Sentence |
denotes |
The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation. |
| TextSentencer_T27 |
1995-2170 |
Sentence |
denotes |
Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles. |
| T23 |
1995-2170 |
Sentence |
denotes |
Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles. |
| T27 |
1995-2170 |
Sentence |
denotes |
Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles. |
| TextSentencer_T28 |
2171-2380 |
Sentence |
denotes |
This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections. |
| T24 |
2171-2380 |
Sentence |
denotes |
This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections. |
| T28 |
2171-2380 |
Sentence |
denotes |
This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections. |