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PubMed:18525076 JSONTXT 49 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR.
T1 0-83 Sentence denotes Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR.
T1 0-83 Sentence denotes Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR.
TextSentencer_T2 84-439 Sentence denotes Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL.
T2 84-439 Sentence denotes Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL.
T2 84-439 Sentence denotes Zwitterionic polysaccharide antigens (ZPSs) were recently shown to activate T cells in a class II major histocompatibility complex (MHCII)-dependent fashion requiring antigen presenting cell (APC)-mediated oxidative processing although little is known about the mechanism or affinity of carbohydrate presentation (Cobb BA, Wang Q, Tzianabos AO, Kasper DL.
TextSentencer_T3 440-445 Sentence denotes 2004.
T3 440-445 Sentence denotes 2004.
T3 440-445 Sentence denotes 2004.
TextSentencer_T4 446-510 Sentence denotes Polysaccharide processing and presentation by the MHCII pathway.
T4 446-510 Sentence denotes Polysaccharide processing and presentation by the MHCII pathway.
T4 446-510 Sentence denotes Polysaccharide processing and presentation by the MHCII pathway.
TextSentencer_T5 511-516 Sentence denotes Cell.
T5 511-516 Sentence denotes Cell.
T5 511-530 Sentence denotes Cell. 117:677-687).
TextSentencer_T6 517-530 Sentence denotes 117:677-687).
T6 517-530 Sentence denotes 117:677-687).
TextSentencer_T7 531-636 Sentence denotes A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL.
T6 531-636 Sentence denotes A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL.
T7 531-636 Sentence denotes A recent study showed that the helical conformation of ZPSs (Wang Y, Kalka-Moll WM, Roehrl MH, Kasper DL.
TextSentencer_T8 637-642 Sentence denotes 2000.
T7 637-642 Sentence denotes 2000.
T8 637-642 Sentence denotes 2000.
TextSentencer_T9 643-730 Sentence denotes Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis.
T8 643-730 Sentence denotes Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis.
T9 643-730 Sentence denotes Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis.
TextSentencer_T10 731-754 Sentence denotes Proc Natl Acad Sci USA.
T9 731-754 Sentence denotes Proc Natl Acad Sci USA.
T10 731-754 Sentence denotes Proc Natl Acad Sci USA.
TextSentencer_T11 755-810 Sentence denotes 97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY.
T10 755-810 Sentence denotes 97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY.
T11 755-810 Sentence denotes 97:13478-13483; Choi YH, Roehrl MH, Kasper DL, Wang JY.
TextSentencer_T12 811-816 Sentence denotes 2002.
T11 811-816 Sentence denotes 2002.
T12 811-816 Sentence denotes 2002.
TextSentencer_T13 817-925 Sentence denotes A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides.
T12 817-925 Sentence denotes A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides.
T13 817-925 Sentence denotes A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides.
TextSentencer_T14 926-939 Sentence denotes Biochemistry.
T14 926-939 Sentence denotes Biochemistry.
T13 926-1062 Sentence denotes Biochemistry. 41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL.
TextSentencer_T15 940-1062 Sentence denotes 41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL.
T15 940-1062 Sentence denotes 41:15144-15151) is closely linked with immunogenic activity (Tzianabos AO, Onderdonk AB, Rosner B, Cisneros RL, Kasper DL.
TextSentencer_T16 1063-1068 Sentence denotes 1993.
T14 1063-1068 Sentence denotes 1993.
T16 1063-1068 Sentence denotes 1993.
TextSentencer_T17 1069-1146 Sentence denotes Structural features of polysaccharides that induce intra-abdominal abscesses.
T15 1069-1146 Sentence denotes Structural features of polysaccharides that induce intra-abdominal abscesses.
T17 1069-1146 Sentence denotes Structural features of polysaccharides that induce intra-abdominal abscesses.
TextSentencer_T18 1147-1155 Sentence denotes Science.
T18 1147-1155 Sentence denotes Science.
T16 1147-1262 Sentence denotes Science. 262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA.
TextSentencer_T19 1156-1262 Sentence denotes 262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA.
T19 1156-1262 Sentence denotes 262:416-419) and is stabilized by a zwitterionic charge motif (Kreisman LS, Friedman JH, Neaga A, Cobb BA.
TextSentencer_T20 1263-1268 Sentence denotes 2007.
T17 1263-1268 Sentence denotes 2007.
T20 1263-1268 Sentence denotes 2007.
TextSentencer_T21 1269-1375 Sentence denotes Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism.
T18 1269-1375 Sentence denotes Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism.
T21 1269-1375 Sentence denotes Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism.
TextSentencer_T22 1376-1389 Sentence denotes Glycobiology.
T22 1376-1389 Sentence denotes Glycobiology.
T19 1376-1466 Sentence denotes Glycobiology. 17:46-55), suggesting a strong carbohydrate structure-function relationship.
TextSentencer_T23 1390-1466 Sentence denotes 17:46-55), suggesting a strong carbohydrate structure-function relationship.
T23 1390-1466 Sentence denotes 17:46-55), suggesting a strong carbohydrate structure-function relationship.
TextSentencer_T24 1467-1647 Sentence denotes In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation.
T20 1467-1647 Sentence denotes In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation.
T24 1467-1647 Sentence denotes In this study, we show that PSA, the ZPS from Bacteroides fragilis, associates with MHCII at high affinity and 1:1 stoichiometry through a mechanism mirroring peptide presentation.
TextSentencer_T25 1648-1788 Sentence denotes Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity.
T21 1648-1788 Sentence denotes Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity.
T25 1648-1788 Sentence denotes Interestingly, PSA binding was mutually exclusive with common MHCII antigens and showed significant allelic differences in binding affinity.
TextSentencer_T26 1789-1994 Sentence denotes The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation.
T22 1789-1994 Sentence denotes The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation.
T26 1789-1994 Sentence denotes The antigen exchange factor HLA-DM that catalyzes peptide antigen association with MHCII also increased the rate of ZPS association and was required for APC presentation and ZPS-mediated T cell activation.
TextSentencer_T27 1995-2170 Sentence denotes Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles.
T23 1995-2170 Sentence denotes Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles.
T27 1995-2170 Sentence denotes Finally, the zwitterionic nature of these antigens was required only for MHCII binding, and not endocytosis, processing, or vesicular trafficking to MHCII-containing vesicles.
TextSentencer_T28 2171-2380 Sentence denotes This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections.
T24 2171-2380 Sentence denotes This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections.
T28 2171-2380 Sentence denotes This report is the first quantitative analysis of the binding mechanism of carbohydrate antigens with MHCII and leads to a novel model for nontraditional MHCII antigen presentation during bacterial infections.