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PubMed:18504438 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-48 Sentence denotes The MYCN oncogene is a direct target of miR-34a.
T1 0-48 Sentence denotes The MYCN oncogene is a direct target of miR-34a.
TextSentencer_T2 49-195 Sentence denotes Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype.
T2 49-195 Sentence denotes Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype.
TextSentencer_T3 196-420 Sentence denotes Database searches identified five microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microRNAs contributes to the malignant phenotype of MYCN-amplified tumors.
T3 196-420 Sentence denotes Database searches identified five microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microRNAs contributes to the malignant phenotype of MYCN-amplified tumors.
TextSentencer_T4 421-695 Sentence denotes By bioinformatic analysis, we identified that three out of the five microRNAs target MYCN and of these miR-34a caused the most significant suppression of cell growth through increased apoptosis and decreased DNA synthesis in neuroblastoma cell lines with MYCN amplification.
T4 421-695 Sentence denotes By bioinformatic analysis, we identified that three out of the five microRNAs target MYCN and of these miR-34a caused the most significant suppression of cell growth through increased apoptosis and decreased DNA synthesis in neuroblastoma cell lines with MYCN amplification.
TextSentencer_T5 696-835 Sentence denotes Quantitative RT-PCR showed that neuroblastoma tumors with 1p36 loss expressed lower level of miR-34a than those with normal copies of 1p36.
T5 696-835 Sentence denotes Quantitative RT-PCR showed that neuroblastoma tumors with 1p36 loss expressed lower level of miR-34a than those with normal copies of 1p36.
TextSentencer_T6 836-905 Sentence denotes Furthermore, we demonstrated that MYCN is a direct target of miR-34a.
T6 836-905 Sentence denotes Furthermore, we demonstrated that MYCN is a direct target of miR-34a.
TextSentencer_T7 906-1145 Sentence denotes Finally, using a series of mRNA expression profiling experiments, we identified other potential direct targets of miR-34a, and pathway analysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related genes.
T7 906-1145 Sentence denotes Finally, using a series of mRNA expression profiling experiments, we identified other potential direct targets of miR-34a, and pathway analysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related genes.
TextSentencer_T8 1146-1264 Sentence denotes This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma.
T8 1146-1264 Sentence denotes This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma.