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Id Subject Object Predicate Lexical cue
T1 0-195 Sentence denotes Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors.
T1 0-195 Sentence denotes Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors.
T2 196-400 Sentence denotes Elevation of intracellular Ca2+ by platelet-derived growth factor (PDGF) and other growth factors involves both release of Ca2+ from intracellular Ca2+ stores and Ca2+ entry from the extracellular medium.
T2 196-400 Sentence denotes Elevation of intracellular Ca2+ by platelet-derived growth factor (PDGF) and other growth factors involves both release of Ca2+ from intracellular Ca2+ stores and Ca2+ entry from the extracellular medium.
T3 401-539 Sentence denotes Release from intracellular stores is believed to be mediated by inositol 1,4,5-trisphosphate (IP3) and the heparin-sensitive IP3 receptor.
T3 401-539 Sentence denotes Release from intracellular stores is believed to be mediated by inositol 1,4,5-trisphosphate (IP3) and the heparin-sensitive IP3 receptor.
T4 540-621 Sentence denotes We studied the mechanism by which entry of extracellular Ca2+ is induced by PDGF.
T4 540-621 Sentence denotes We studied the mechanism by which entry of extracellular Ca2+ is induced by PDGF.
T5 622-756 Sentence denotes Intracellular free Ca2+ (Ca2+i) was measured in single cultured rat vascular smooth muscle cells using fura 2 microspectrofluorometry.
T5 622-756 Sentence denotes Intracellular free Ca2+ (Ca2+i) was measured in single cultured rat vascular smooth muscle cells using fura 2 microspectrofluorometry.
T6 757-993 Sentence denotes In nominally Ca2(+)-free medium, PDGF (recombinant BB, 10 ng/ml) raised intracellular Ca2+ transiently (less than 5 min); addition of 2 mM Ca2+ to the bathing medium after 5 min caused a second, prolonged increase in intracellular Ca2+.
T6 757-993 Sentence denotes In nominally Ca2(+)-free medium, PDGF (recombinant BB, 10 ng/ml) raised intracellular Ca2+ transiently (less than 5 min); addition of 2 mM Ca2+ to the bathing medium after 5 min caused a second, prolonged increase in intracellular Ca2+.
T7 994-1124 Sentence denotes Repeated changes in extracellular Ca2+ from 0 to 2 mM over 90 min caused rapid, parallel changes in Ca2+i of approximately 200 nM.
T7 994-1124 Sentence denotes Repeated changes in extracellular Ca2+ from 0 to 2 mM over 90 min caused rapid, parallel changes in Ca2+i of approximately 200 nM.
T8 1125-1255 Sentence denotes This change in Ca2+i in response to changes in extracellular Ca2+ was virtually undetectable in control or thrombin-treated cells.
T8 1125-1255 Sentence denotes This change in Ca2+i in response to changes in extracellular Ca2+ was virtually undetectable in control or thrombin-treated cells.
T9 1256-1391 Sentence denotes The intracellular response to changes in medium Ca2+ after PDGF was completely blocked by 10 mM CoCl2, but not by 10(-7) M nicardipine.
T9 1256-1391 Sentence denotes The intracellular response to changes in medium Ca2+ after PDGF was completely blocked by 10 mM CoCl2, but not by 10(-7) M nicardipine.
T10 1392-1594 Sentence denotes Microinjection of monoclonal antibodies to phosphatidylinositol 4,5-bisphosphate (PIP2) (kt 10, 2 mg/ml) totally abolished both mobilization of intracellular Ca2+ stores and entry of extracellular Ca2+.
T10 1392-1594 Sentence denotes Microinjection of monoclonal antibodies to phosphatidylinositol 4,5-bisphosphate (PIP2) (kt 10, 2 mg/ml) totally abolished both mobilization of intracellular Ca2+ stores and entry of extracellular Ca2+.
T11 1595-1808 Sentence denotes Consistent with this finding, maintenance of Ca2+ entry required ongoing receptor occupancy, since displacement of PDGF from its receptor with suramin (1 mM) eradicated extracellular Ca2+ entry in less than 5 min.
T11 1595-1808 Sentence denotes Consistent with this finding, maintenance of Ca2+ entry required ongoing receptor occupancy, since displacement of PDGF from its receptor with suramin (1 mM) eradicated extracellular Ca2+ entry in less than 5 min.
T12 1809-1974 Sentence denotes To determine whether extracellular Ca2+ entry involves the heparin-sensitive IP3 receptor, cells were microinjected with heparin (4 mg/ml) prior to addition of PDGF.
T12 1809-1974 Sentence denotes To determine whether extracellular Ca2+ entry involves the heparin-sensitive IP3 receptor, cells were microinjected with heparin (4 mg/ml) prior to addition of PDGF.
T13 1975-2109 Sentence denotes Heparin, but not chondroitin sulfate, prevented mobilization of intracellular Ca2+ stores but did not affect extracellular Ca2+ entry.
T13 1975-2109 Sentence denotes Heparin, but not chondroitin sulfate, prevented mobilization of intracellular Ca2+ stores but did not affect extracellular Ca2+ entry.
T14 2110-2191 Sentence denotes We PDGF requires ongoing receptor occupancy and involves PIP2 or PIP2 metabolism.
T14 2110-2191 Sentence denotes We PDGF requires ongoing receptor occupancy and involves PIP2 or PIP2 metabolism.
T15 2192-2303 Sentence denotes However, the signal which mediates PDGF-induced Ca2+ entry does not require the heparin-sensitive IP3 receptor.
T15 2192-2303 Sentence denotes However, the signal which mediates PDGF-induced Ca2+ entry does not require the heparin-sensitive IP3 receptor.