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PubMed:18450757 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
T1 0-100 Sentence denotes Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
T2 101-313 Sentence denotes Upon antigen recognition, T-cell receptor (TCR/CD3) and other signaling molecules become enriched in a specialized contact site between the T cell and antigen-presenting cell, i.e. the immunological synapse (IS).
T2 101-313 Sentence denotes Upon antigen recognition, T-cell receptor (TCR/CD3) and other signaling molecules become enriched in a specialized contact site between the T cell and antigen-presenting cell, i.e. the immunological synapse (IS).
T3 314-462 Sentence denotes Enrichment occurs via mechanisms that include polarized secretion from recycling endosomes, but the Rabs and RabGAPs that regulate this are unknown.
T3 314-462 Sentence denotes Enrichment occurs via mechanisms that include polarized secretion from recycling endosomes, but the Rabs and RabGAPs that regulate this are unknown.
T4 463-657 Sentence denotes EPI64C (TBC1D10C) is an uncharacterized candidate RabGAP we identified by mass spectrometry as abundant in human peripheral blood T cells that is preferentially expressed in hematopoietic cells.
T4 463-657 Sentence denotes EPI64C (TBC1D10C) is an uncharacterized candidate RabGAP we identified by mass spectrometry as abundant in human peripheral blood T cells that is preferentially expressed in hematopoietic cells.
T5 658-767 Sentence denotes EPI64C is a Rab35-GAP based both on in vitro Rab35-specific GAP activity and findings in transfection assays.
T5 658-767 Sentence denotes EPI64C is a Rab35-GAP based both on in vitro Rab35-specific GAP activity and findings in transfection assays.
T6 768-1008 Sentence denotes EPI64C and Rab35 dominant negative (DN) constructs each impaired transferrin export from a recycling pathway in Jurkat T-cells and induced large vacuoles marked by transferrin receptor, TCR, and SNAREs implicated in TCR-polarized secretion.
T6 768-1008 Sentence denotes EPI64C and Rab35 dominant negative (DN) constructs each impaired transferrin export from a recycling pathway in Jurkat T-cells and induced large vacuoles marked by transferrin receptor, TCR, and SNAREs implicated in TCR-polarized secretion.
T7 1009-1135 Sentence denotes Rab35 localized to the plasma membrane and to intracellular vesicles where it substantially colocalized with TfR and with TCR.
T7 1009-1135 Sentence denotes Rab35 localized to the plasma membrane and to intracellular vesicles where it substantially colocalized with TfR and with TCR.
T8 1136-1175 Sentence denotes Rab35 was strongly recruited to the IS.
T8 1136-1175 Sentence denotes Rab35 was strongly recruited to the IS.
T9 1176-1274 Sentence denotes Conjugate formation was impaired by transfection with Rab35-DN or EPI64C and by EPI64C knock down.
T9 1176-1274 Sentence denotes Conjugate formation was impaired by transfection with Rab35-DN or EPI64C and by EPI64C knock down.
T10 1275-1325 Sentence denotes TCR enrichment at the IS was impaired by Rab35-DN.
T10 1275-1325 Sentence denotes TCR enrichment at the IS was impaired by Rab35-DN.
T11 1326-1477 Sentence denotes Thus, EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to IS formation, most likely by participating in TCR transport to the IS.
T11 1326-1477 Sentence denotes Thus, EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to IS formation, most likely by participating in TCR transport to the IS.