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PubMed:18443194 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-123 Sentence denotes Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients.
T1 0-123 Sentence denotes Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients.
TextSentencer_T2 124-134 Sentence denotes OBJECTIVE:
T2 124-134 Sentence denotes OBJECTIVE:
TextSentencer_T3 135-277 Sentence denotes To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes.
T3 135-277 Sentence denotes To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes.
TextSentencer_T4 278-306 Sentence denotes RESEARCH DESIGN AND METHODS:
T4 278-306 Sentence denotes RESEARCH DESIGN AND METHODS:
TextSentencer_T5 307-501 Sentence denotes We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369).
T5 307-501 Sentence denotes We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369).
TextSentencer_T6 502-570 Sentence denotes We also assessed serum levels of the soluble form of CTLA4 (sCTLA4).
T6 502-570 Sentence denotes We also assessed serum levels of the soluble form of CTLA4 (sCTLA4).
TextSentencer_T7 571-579 Sentence denotes RESULTS:
T7 571-579 Sentence denotes RESULTS:
TextSentencer_T8 580-661 Sentence denotes The +49GG and CT60GG genotypes were associated with type 1A diabetes (P < 0.001).
T8 580-661 Sentence denotes The +49GG and CT60GG genotypes were associated with type 1A diabetes (P < 0.001).
TextSentencer_T9 662-835 Sentence denotes In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01).
T9 662-835 Sentence denotes In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01).
TextSentencer_T10 836-942 Sentence denotes Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P < 0.05).
T10 836-942 Sentence denotes Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P < 0.05).
TextSentencer_T11 943-955 Sentence denotes CONCLUSIONS:
T11 943-955 Sentence denotes CONCLUSIONS:
TextSentencer_T12 956-1058 Sentence denotes These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes.
T12 956-1058 Sentence denotes These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes.
TextSentencer_T13 1059-1199 Sentence denotes Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes.
T13 1059-1199 Sentence denotes Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes.