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PubMed:18408010 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-48 Sentence denotes A mutation in telethonin alters Nav1.5 function.
T1 0-48 Sentence denotes A mutation in telethonin alters Nav1.5 function.
TextSentencer_T2 49-162 Sentence denotes Excitable cells express a variety of ion channels that allow rapid exchange of ions with the extracellular space.
T2 49-162 Sentence denotes Excitable cells express a variety of ion channels that allow rapid exchange of ions with the extracellular space.
TextSentencer_T3 163-263 Sentence denotes Opening of Na(+) channels in excitable cells results in influx of Na(+) and cellular depolarization.
T3 163-263 Sentence denotes Opening of Na(+) channels in excitable cells results in influx of Na(+) and cellular depolarization.
TextSentencer_T4 264-401 Sentence denotes The function of Na(v)1.5, an Na(+) channel expressed in the heart, brain, and gastrointestinal tract, is altered by interacting proteins.
T4 264-401 Sentence denotes The function of Na(v)1.5, an Na(+) channel expressed in the heart, brain, and gastrointestinal tract, is altered by interacting proteins.
TextSentencer_T5 402-469 Sentence denotes The pore-forming alpha-subunit of this channel is encoded by SCN5A.
T5 402-469 Sentence denotes The pore-forming alpha-subunit of this channel is encoded by SCN5A.
TextSentencer_T6 470-604 Sentence denotes Genetic perturbations in SCN5A cause type 3 long QT syndrome and type 1 Brugada syndrome, two distinct heritable arrhythmia syndromes.
T6 470-604 Sentence denotes Genetic perturbations in SCN5A cause type 3 long QT syndrome and type 1 Brugada syndrome, two distinct heritable arrhythmia syndromes.
TextSentencer_T7 605-840 Sentence denotes Mutations in SCN5A are also associated with increased prevalence of gastrointestinal symptoms, suggesting that the Na(+) channel plays a role in normal gastrointestinal physiology and that alterations in its function may cause disease.
T7 605-840 Sentence denotes Mutations in SCN5A are also associated with increased prevalence of gastrointestinal symptoms, suggesting that the Na(+) channel plays a role in normal gastrointestinal physiology and that alterations in its function may cause disease.
TextSentencer_T8 841-1039 Sentence denotes We collected blood from patients with intestinal pseudo-obstruction (a disease associated with abnormal motility in the gut) and screened for mutations in SCN5A and ion channel-interacting proteins.
T8 841-1039 Sentence denotes We collected blood from patients with intestinal pseudo-obstruction (a disease associated with abnormal motility in the gut) and screened for mutations in SCN5A and ion channel-interacting proteins.
TextSentencer_T9 1040-1156 Sentence denotes A 42-year-old male patient was found to have a mutation in the gene TCAP, encoding for the small protein telethonin.
T9 1040-1156 Sentence denotes A 42-year-old male patient was found to have a mutation in the gene TCAP, encoding for the small protein telethonin.
TextSentencer_T10 1157-1314 Sentence denotes Telethonin was found to be expressed in the human gastrointestinal smooth muscle, co-localized with Na(v)1.5, and co-immunoprecipitated with sodium channels.
T10 1157-1314 Sentence denotes Telethonin was found to be expressed in the human gastrointestinal smooth muscle, co-localized with Na(v)1.5, and co-immunoprecipitated with sodium channels.
TextSentencer_T11 1315-1493 Sentence denotes Expression of mutated telethonin, when co-expressed with SCN5A in HEK 293 cells, altered steady state activation kinetics of SCN5A, resulting in a doubling of the window current.
T11 1315-1493 Sentence denotes Expression of mutated telethonin, when co-expressed with SCN5A in HEK 293 cells, altered steady state activation kinetics of SCN5A, resulting in a doubling of the window current.
TextSentencer_T12 1494-1606 Sentence denotes These results suggest a new role for telethonin, namely that telethonin is a sodium channel-interacting protein.
T12 1494-1606 Sentence denotes These results suggest a new role for telethonin, namely that telethonin is a sodium channel-interacting protein.
TextSentencer_T13 1607-1718 Sentence denotes Also, mutations in telethonin can alter Na(v)1.5 kinetics and may play a role in intestinal pseudo-obstruction.
T13 1607-1718 Sentence denotes Also, mutations in telethonin can alter Na(v)1.5 kinetics and may play a role in intestinal pseudo-obstruction.