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PubMed:18376396 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-104 Sentence denotes The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
T1 0-104 Sentence denotes The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
TextSentencer_T2 105-270 Sentence denotes Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis.
T2 105-270 Sentence denotes Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis.
TextSentencer_T3 271-571 Sentence denotes We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or to ectopic expression of the protein tyrosine phosphatase Pez.
T3 271-571 Sentence denotes We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or to ectopic expression of the protein tyrosine phosphatase Pez.
TextSentencer_T4 572-667 Sentence denotes Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT.
T4 572-667 Sentence denotes Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT.
TextSentencer_T5 668-893 Sentence denotes Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis.
T5 668-893 Sentence denotes Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis.
TextSentencer_T6 894-1007 Sentence denotes Inhibition of the microRNAs was sufficient to induce EMT in a process requiring upregulation of ZEB1 and/or SIP1.
T6 894-1007 Sentence denotes Inhibition of the microRNAs was sufficient to induce EMT in a process requiring upregulation of ZEB1 and/or SIP1.
TextSentencer_T7 1008-1132 Sentence denotes Conversely, ectopic expression of these microRNAs in mesenchymal cells initiated mesenchymal to epithelial transition (MET).
T7 1008-1132 Sentence denotes Conversely, ectopic expression of these microRNAs in mesenchymal cells initiated mesenchymal to epithelial transition (MET).
TextSentencer_T8 1133-1294 Sentence denotes Consistent with their role in regulating EMT, expression of these microRNAs was found to be lost in invasive breast cancer cell lines with mesenchymal phenotype.
T8 1133-1294 Sentence denotes Consistent with their role in regulating EMT, expression of these microRNAs was found to be lost in invasive breast cancer cell lines with mesenchymal phenotype.
TextSentencer_T9 1295-1411 Sentence denotes Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin.
T9 1295-1411 Sentence denotes Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin.
TextSentencer_T10 1412-1515 Sentence denotes These data suggest that downregulation of the microRNAs may be an important step in tumour progression.
T10 1412-1515 Sentence denotes These data suggest that downregulation of the microRNAs may be an important step in tumour progression.