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PubMed:18356166 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus.
T1 0-71 Sentence denotes A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus.
T2 72-224 Sentence denotes Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood.
T2 72-224 Sentence denotes Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood.
T3 225-331 Sentence denotes E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by gamma-secretase.
T3 225-331 Sentence denotes E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by gamma-secretase.
T4 332-445 Sentence denotes This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol.
T4 332-445 Sentence denotes This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol.
T5 446-500 Sentence denotes Here, we study the fate and function of this fragment.
T5 446-500 Sentence denotes Here, we study the fate and function of this fragment.
T6 501-637 Sentence denotes First, we show that coexpression of the cadherin-binding protein, p120 catenin (p120), enhances the nuclear translocation of E-cad/CTF2.
T6 501-637 Sentence denotes First, we show that coexpression of the cadherin-binding protein, p120 catenin (p120), enhances the nuclear translocation of E-cad/CTF2.
T7 638-774 Sentence denotes By knocking down p120 with short interfering RNA, we also demonstrate that p120 is necessary for the nuclear localization of E-cad/CTF2.
T7 638-774 Sentence denotes By knocking down p120 with short interfering RNA, we also demonstrate that p120 is necessary for the nuclear localization of E-cad/CTF2.
T8 775-864 Sentence denotes Furthermore, p120 enhances and is required for the specific binding of E-cad/CTF2 to DNA.
T8 775-864 Sentence denotes Furthermore, p120 enhances and is required for the specific binding of E-cad/CTF2 to DNA.
T9 865-968 Sentence denotes Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus.
T9 865-968 Sentence denotes Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus.
T10 969-1040 Sentence denotes These data indicate a novel role for cleaved E-cadherin in the nucleus.
T10 969-1040 Sentence denotes These data indicate a novel role for cleaved E-cadherin in the nucleus.