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PubMed:18287095 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.
T2 87-226 Sentence denotes Interferons regulate diverse immune functions through the transcriptional activation of hundreds of genes involved in anti-viral responses.
T3 227-453 Sentence denotes The interferon-inducible ubiquitin-like protein ISG15 is expressed in cells in response to a variety of stress conditions like viral or bacterial infection and is present in its free form or is conjugated to cellular proteins.
T4 454-535 Sentence denotes In addition, protein ubiquitination plays a regulatory role in the immune system.
T5 536-640 Sentence denotes Many viruses modulate the ubiquitin (Ub) pathway to alter cellular signaling and the antiviral response.
T6 641-869 Sentence denotes Ubiquitination of retroviral group-specific antigen precursors and matrix proteins of the Ebola, vesicular stomatitis, and rabies viruses by Nedd4 family HECT domain E3 ligases is an important step in facilitating viral release.
T7 870-923 Sentence denotes We found that Nedd4 is negatively regulated by ISG15.
T8 924-1063 Sentence denotes Free ISG15 specifically bound to Nedd4 and blocked its interaction with Ub-E2 molecules, thus preventing further Ub transfer from E2 to E3.
T9 1064-1258 Sentence denotes Furthermore, overexpression of ISG15 diminished the ability of Nedd4 to ubiquitinate viral matrix proteins and led to a decrease in the release of Ebola VP40 virus-like particles from the cells.
T10 1259-1429 Sentence denotes These results point to a mechanistically novel function of ISG15 in the enhancement of the innate anti-viral response through specific inhibition of Nedd4 Ub-E3 activity.
T11 1430-1589 Sentence denotes To our knowledge, this is the first example of a Ub-like protein with the ability to interfere with Ub-E2 and E3 interaction to inhibit protein ubiquitination.