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PubMed:18234963 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.
T1 0-124 Sentence denotes TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.
TextSentencer_T2 125-188 Sentence denotes p53 family proteins include p53 tumor suppressor, p63, and p73.
T2 125-188 Sentence denotes p53 family proteins include p53 tumor suppressor, p63, and p73.
TextSentencer_T3 189-319 Sentence denotes Despite the high similarity in structure and function with p53, p63, and p73 function in tumor suppression is still controversial.
T3 189-319 Sentence denotes Despite the high similarity in structure and function with p53, p63, and p73 function in tumor suppression is still controversial.
TextSentencer_T4 320-466 Sentence denotes Here, we show that TAp73alpha, a transcriptionally active p73 isoform, is able to synergize p53 tumor suppressor function in thyroid cancer cells.
T4 320-466 Sentence denotes Here, we show that TAp73alpha, a transcriptionally active p73 isoform, is able to synergize p53 tumor suppressor function in thyroid cancer cells.
TextSentencer_T5 467-595 Sentence denotes Indeed, depletion of p73 by small interfering RNA in thyroid cancer cells resulted in a reduced transcriptional activity of p53.
T5 467-595 Sentence denotes Indeed, depletion of p73 by small interfering RNA in thyroid cancer cells resulted in a reduced transcriptional activity of p53.
TextSentencer_T6 596-816 Sentence denotes Ectopic coexpression of both p53 and TAp73alpha in thyroid cancer cells resulted in increased transcription and tumor suppressor function compared with p53 or TAp73alpha alone, as well as in increased p53 protein levels.
T6 596-816 Sentence denotes Ectopic coexpression of both p53 and TAp73alpha in thyroid cancer cells resulted in increased transcription and tumor suppressor function compared with p53 or TAp73alpha alone, as well as in increased p53 protein levels.
TextSentencer_T7 817-953 Sentence denotes The enhancing effect of TAp73alpha on p53 activity is Mdm2 dependent because it is prevented by Mdm2 depletion by small interfering RNA.
T7 817-953 Sentence denotes The enhancing effect of TAp73alpha on p53 activity is Mdm2 dependent because it is prevented by Mdm2 depletion by small interfering RNA.
TextSentencer_T8 954-1039 Sentence denotes At least two mechanisms may explain the interference of TAp73alpha with p53 function.
T8 954-1039 Sentence denotes At least two mechanisms may explain the interference of TAp73alpha with p53 function.
TextSentencer_T9 1040-1175 Sentence denotes First, in thyroid cancer cells, TAp73alpha inhibits the effect of p53 on Mdm2 induction by antagonizing p53 at the Mdm2 promoter level.
T9 1040-1175 Sentence denotes First, in thyroid cancer cells, TAp73alpha inhibits the effect of p53 on Mdm2 induction by antagonizing p53 at the Mdm2 promoter level.
TextSentencer_T10 1176-1348 Sentence denotes Second, a TAp73alpha mutant (G264W), which is devoid of DNA binding capability, is still able to increase p53 protein levels by competing with p53 for Mdm2 protein binding.
T10 1176-1348 Sentence denotes Second, a TAp73alpha mutant (G264W), which is devoid of DNA binding capability, is still able to increase p53 protein levels by competing with p53 for Mdm2 protein binding.
TextSentencer_T11 1349-1530 Sentence denotes Taken together, these results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation.
T11 1349-1530 Sentence denotes Taken together, these results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation.
TextSentencer_T12 1531-1653 Sentence denotes These results may be useful for designing gene therapies aimed at restoring a normal p53 function in thyroid cancer cells.
T12 1531-1653 Sentence denotes These results may be useful for designing gene therapies aimed at restoring a normal p53 function in thyroid cancer cells.