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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes Biosynthesis, processing, and secretion of alpha-L-fucosidase in lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy.
T1 0-146 Sentence denotes Biosynthesis, processing, and secretion of alpha-L-fucosidase in lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy.
T1 0-146 Sentence denotes Biosynthesis, processing, and secretion of alpha-L-fucosidase in lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy.
TextSentencer_T2 147-354 Sentence denotes N-Acetylglucosamine 1-phosphotransferase is a key enzyme required for synthesis of the mannose 6-phosphate recognition marker that is used by many newly made acid hydrolases for their transport to lysosomes.
T2 147-354 Sentence denotes N-Acetylglucosamine 1-phosphotransferase is a key enzyme required for synthesis of the mannose 6-phosphate recognition marker that is used by many newly made acid hydrolases for their transport to lysosomes.
T2 147-354 Sentence denotes N-Acetylglucosamine 1-phosphotransferase is a key enzyme required for synthesis of the mannose 6-phosphate recognition marker that is used by many newly made acid hydrolases for their transport to lysosomes.
TextSentencer_T3 355-636 Sentence denotes It has previously been found that lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy have nearly normal intracellular and intralysosomal activities of several lysosomal acid hydrolases, despite a deficiency of N-acetylglucosamine 1-phosphotransferase.
T3 355-636 Sentence denotes It has previously been found that lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy have nearly normal intracellular and intralysosomal activities of several lysosomal acid hydrolases, despite a deficiency of N-acetylglucosamine 1-phosphotransferase.
T3 355-636 Sentence denotes It has previously been found that lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy have nearly normal intracellular and intralysosomal activities of several lysosomal acid hydrolases, despite a deficiency of N-acetylglucosamine 1-phosphotransferase.
TextSentencer_T4 637-801 Sentence denotes These results suggest that lymphoid cells may provide an important system to investigate alternate mechanisms for targeting newly made acid hydrolases to lysosomes.
T4 637-801 Sentence denotes These results suggest that lymphoid cells may provide an important system to investigate alternate mechanisms for targeting newly made acid hydrolases to lysosomes.
T4 637-801 Sentence denotes These results suggest that lymphoid cells may provide an important system to investigate alternate mechanisms for targeting newly made acid hydrolases to lysosomes.
TextSentencer_T5 802-1001 Sentence denotes In the present study, the biosynthesis, processing and secretion of alpha-L-fucosidase in I-cell and pseudo-Hurler lymphoid cells was used as a model system to study the existence of such mechanisms.
T5 802-1001 Sentence denotes In the present study, the biosynthesis, processing and secretion of alpha-L-fucosidase in I-cell and pseudo-Hurler lymphoid cells was used as a model system to study the existence of such mechanisms.
T5 802-1001 Sentence denotes In the present study, the biosynthesis, processing and secretion of alpha-L-fucosidase in I-cell and pseudo-Hurler lymphoid cells was used as a model system to study the existence of such mechanisms.
TextSentencer_T6 1002-1196 Sentence denotes The level of intracellular alpha-L-fucosidase protein in exponentially growing I-cell or pseudo-Hurler lymphoid cultures was statistically indistinguishable from the mean of 19 control cultures.
T6 1002-1196 Sentence denotes The level of intracellular alpha-L-fucosidase protein in exponentially growing I-cell or pseudo-Hurler lymphoid cultures was statistically indistinguishable from the mean of 19 control cultures.
T6 1002-1196 Sentence denotes The level of intracellular alpha-L-fucosidase protein in exponentially growing I-cell or pseudo-Hurler lymphoid cultures was statistically indistinguishable from the mean of 19 control cultures.
TextSentencer_T7 1197-1379 Sentence denotes A 1.5 h [35S]methionine pulse experiment showed that alpha-L-fucosidase is initially synthesized by I-cell, pseudo-Hurler and control cultures as an intracellular form (Mr = 58,000).
T7 1197-1379 Sentence denotes A 1.5 h [35S]methionine pulse experiment showed that alpha-L-fucosidase is initially synthesized by I-cell, pseudo-Hurler and control cultures as an intracellular form (Mr = 58,000).
T7 1197-1379 Sentence denotes A 1.5 h [35S]methionine pulse experiment showed that alpha-L-fucosidase is initially synthesized by I-cell, pseudo-Hurler and control cultures as an intracellular form (Mr = 58,000).
TextSentencer_T8 1380-1537 Sentence denotes Companion cultures chased with methionine from 2 to 21 h processed the enzyme to an intracellular form (Mr = 60,000) and an extracellular form (Mr = 62,000).
T8 1380-1537 Sentence denotes Companion cultures chased with methionine from 2 to 21 h processed the enzyme to an intracellular form (Mr = 60,000) and an extracellular form (Mr = 62,000).
T8 1380-1537 Sentence denotes Companion cultures chased with methionine from 2 to 21 h processed the enzyme to an intracellular form (Mr = 60,000) and an extracellular form (Mr = 62,000).
TextSentencer_T9 1538-1611 Sentence denotes All enzyme forms were glycoproteins with polypeptide chains of Mr 52,000.
T9 1538-1611 Sentence denotes All enzyme forms were glycoproteins with polypeptide chains of Mr 52,000.
T9 1538-1611 Sentence denotes All enzyme forms were glycoproteins with polypeptide chains of Mr 52,000.
TextSentencer_T10 1612-1831 Sentence denotes In control cells incubated with radioactive inorganic phosphate (32Pi), less than 1% of the 32Pi incorporated into alpha-L-fucosidase was associated with carbohydrate chains and greater than 99% with polypeptide chains.
T10 1612-1831 Sentence denotes In control cells incubated with radioactive inorganic phosphate (32Pi), less than 1% of the 32Pi incorporated into alpha-L-fucosidase was associated with carbohydrate chains and greater than 99% with polypeptide chains.
T10 1612-1831 Sentence denotes In control cells incubated with radioactive inorganic phosphate (32Pi), less than 1% of the 32Pi incorporated into alpha-L-fucosidase was associated with carbohydrate chains and greater than 99% with polypeptide chains.
TextSentencer_T11 1832-1958 Sentence denotes In I-cell disease lymphoid cells, the 32Pi incorporated into alpha-L-fucosidase was associated solely with polypeptide chains.
T11 1832-1958 Sentence denotes In I-cell disease lymphoid cells, the 32Pi incorporated into alpha-L-fucosidase was associated solely with polypeptide chains.
T11 1832-1958 Sentence denotes In I-cell disease lymphoid cells, the 32Pi incorporated into alpha-L-fucosidase was associated solely with polypeptide chains.
TextSentencer_T12 1959-2095 Sentence denotes A qualitative analysis of phosphorylated residues identified phosphoserine in alpha-L-fucosidase from control and I-cell lymphoid cells.
T12 1959-2095 Sentence denotes A qualitative analysis of phosphorylated residues identified phosphoserine in alpha-L-fucosidase from control and I-cell lymphoid cells.
T12 1959-2095 Sentence denotes A qualitative analysis of phosphorylated residues identified phosphoserine in alpha-L-fucosidase from control and I-cell lymphoid cells.
TextSentencer_T13 2096-2169 Sentence denotes Only alpha-L-fucosidase from control cells contained mannose 6-phosphate.
T13 2096-2169 Sentence denotes Only alpha-L-fucosidase from control cells contained mannose 6-phosphate.
T13 2096-2169 Sentence denotes Only alpha-L-fucosidase from control cells contained mannose 6-phosphate.
TextSentencer_T14 2170-2327 Sentence denotes These results are consistent with the proposal that I-cell lymphoid cells may use a mannose 6-phosphate-independent mechanism for routing alpha-L-fucosidase.
T14 2170-2327 Sentence denotes These results are consistent with the proposal that I-cell lymphoid cells may use a mannose 6-phosphate-independent mechanism for routing alpha-L-fucosidase.
T14 2170-2327 Sentence denotes These results are consistent with the proposal that I-cell lymphoid cells may use a mannose 6-phosphate-independent mechanism for routing alpha-L-fucosidase.
TextSentencer_T15 2328-2536 Sentence denotes Additional metabolic labelling experiments demonstrated the presence of 32P-labelled alpha-L-fucosidase in both cells and medium of a control lymphoid culture, but only in cells of an I-cell lymphoid culture.
T15 2328-2536 Sentence denotes Additional metabolic labelling experiments demonstrated the presence of 32P-labelled alpha-L-fucosidase in both cells and medium of a control lymphoid culture, but only in cells of an I-cell lymphoid culture.
T15 2328-2536 Sentence denotes Additional metabolic labelling experiments demonstrated the presence of 32P-labelled alpha-L-fucosidase in both cells and medium of a control lymphoid culture, but only in cells of an I-cell lymphoid culture.
TextSentencer_T16 2537-2669 Sentence denotes In contrast, alpha-L-fucosidase labelled with [35S]methionine was found in cells and medium of control and I-cell lymphoid cultures.
T16 2537-2669 Sentence denotes In contrast, alpha-L-fucosidase labelled with [35S]methionine was found in cells and medium of control and I-cell lymphoid cultures.
T16 2537-2669 Sentence denotes In contrast, alpha-L-fucosidase labelled with [35S]methionine was found in cells and medium of control and I-cell lymphoid cultures.
TextSentencer_T17 2670-2921 Sentence denotes Since phosphoserine was only found to occur in intracellular, but not in extracellular alpha-L-fucosidase of the I-cell culture, we speculate that phosphoserine may be involved in intracellular retention of alpha-L-fucosidase in I-cell lymphoid cells.
T17 2670-2921 Sentence denotes Since phosphoserine was only found to occur in intracellular, but not in extracellular alpha-L-fucosidase of the I-cell culture, we speculate that phosphoserine may be involved in intracellular retention of alpha-L-fucosidase in I-cell lymphoid cells.
T17 2670-2921 Sentence denotes Since phosphoserine was only found to occur in intracellular, but not in extracellular alpha-L-fucosidase of the I-cell culture, we speculate that phosphoserine may be involved in intracellular retention of alpha-L-fucosidase in I-cell lymphoid cells.