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PubMed:18180299 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.
T1 0-139 Sentence denotes Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.
T2 140-270 Sentence denotes CCR4-NOT is an evolutionarily conserved, multicomponent complex known to be involved in transcription as well as mRNA degradation.
T2 140-270 Sentence denotes CCR4-NOT is an evolutionarily conserved, multicomponent complex known to be involved in transcription as well as mRNA degradation.
T3 271-401 Sentence denotes Various subunits (e.g. CNOT1 and CNOT7/CAF1) have been reported to be involved in influencing nuclear hormone receptor activities.
T3 271-401 Sentence denotes Various subunits (e.g. CNOT1 and CNOT7/CAF1) have been reported to be involved in influencing nuclear hormone receptor activities.
T4 402-518 Sentence denotes Here, we show that CCR4/CNOT6 and RCD1/CNOT9, members of the CCR4-NOT complex, potentiate nuclear receptor activity.
T4 402-518 Sentence denotes Here, we show that CCR4/CNOT6 and RCD1/CNOT9, members of the CCR4-NOT complex, potentiate nuclear receptor activity.
T5 519-711 Sentence denotes RCD1 interacts in vivo and in vitro with NIF-1 (NRC-interacting factor), a previously characterized nuclear receptor cotransducer that activates nuclear receptors via its interaction with NRC.
T5 519-711 Sentence denotes RCD1 interacts in vivo and in vitro with NIF-1 (NRC-interacting factor), a previously characterized nuclear receptor cotransducer that activates nuclear receptors via its interaction with NRC.
T6 712-886 Sentence denotes As with NIF-1, RCD1 and CCR4 do not directly associate with nuclear receptors; however, they enhance ligand-dependent transcriptional activation by nuclear hormone receptors.
T6 712-886 Sentence denotes As with NIF-1, RCD1 and CCR4 do not directly associate with nuclear receptors; however, they enhance ligand-dependent transcriptional activation by nuclear hormone receptors.
T7 887-1092 Sentence denotes CCR4 mediates its effect through the ligand binding domain of nuclear receptors and small interference RNA-mediated silencing of endogenous CCR4 results in a marked decrease in nuclear receptor activation.
T7 887-1092 Sentence denotes CCR4 mediates its effect through the ligand binding domain of nuclear receptors and small interference RNA-mediated silencing of endogenous CCR4 results in a marked decrease in nuclear receptor activation.
T8 1093-1244 Sentence denotes Furthermore, knockdown of CCR4 results in an attenuated stimulation of RARalpha target genes (e.g. Sox9 and HoxA1) as shown by quantitative PCR assays.
T8 1093-1244 Sentence denotes Furthermore, knockdown of CCR4 results in an attenuated stimulation of RARalpha target genes (e.g. Sox9 and HoxA1) as shown by quantitative PCR assays.
T9 1245-1371 Sentence denotes The silencing of endogenous NIF-1 also resulted in a comparable decrease in the RAR-mediated induction of both Sox9 and HoxA1.
T9 1245-1371 Sentence denotes The silencing of endogenous NIF-1 also resulted in a comparable decrease in the RAR-mediated induction of both Sox9 and HoxA1.
T10 1372-1420 Sentence denotes Furthermore, CCR4 associates in vivo with NIF-1.
T10 1372-1420 Sentence denotes Furthermore, CCR4 associates in vivo with NIF-1.
T11 1421-1522 Sentence denotes In addition, the CCR4-enhanced transcriptional activation by nuclear receptors is dependent on NIF-1.
T11 1421-1522 Sentence denotes In addition, the CCR4-enhanced transcriptional activation by nuclear receptors is dependent on NIF-1.
T12 1523-1634 Sentence denotes The small interference RNA-mediated knockdown of NIF-1 blocks the ligand-dependent potentiating effect of CCR4.
T12 1523-1634 Sentence denotes The small interference RNA-mediated knockdown of NIF-1 blocks the ligand-dependent potentiating effect of CCR4.
T13 1635-1829 Sentence denotes Our results suggest that CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and that RCD1 and CCR4 might mediate their function through their interaction with NIF-1.
T13 1635-1829 Sentence denotes Our results suggest that CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and that RCD1 and CCR4 might mediate their function through their interaction with NIF-1.