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PubMed:18180295 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
T1 0-118 Sentence denotes Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
T2 119-231 Sentence denotes beta-Defensins are important in mammalian immunity displaying both antimicrobial and chemoattractant activities.
T2 119-231 Sentence denotes beta-Defensins are important in mammalian immunity displaying both antimicrobial and chemoattractant activities.
T3 232-379 Sentence denotes Three canonical disulfide intramolecular bonds are believed to be dispensable for antimicrobial activity but essential for chemoattractant ability.
T3 232-379 Sentence denotes Three canonical disulfide intramolecular bonds are believed to be dispensable for antimicrobial activity but essential for chemoattractant ability.
T4 380-532 Sentence denotes However, here we show that HBD3 (human beta-defensin 3) alkylated with iodoactemide and devoid of any disulfide bonds is still a potent chemoattractant.
T4 380-532 Sentence denotes However, here we show that HBD3 (human beta-defensin 3) alkylated with iodoactemide and devoid of any disulfide bonds is still a potent chemoattractant.
T5 533-667 Sentence denotes Furthermore, when the canonical six cysteine residues are replaced with alanine, the peptide is no longer active as a chemoattractant.
T5 533-667 Sentence denotes Furthermore, when the canonical six cysteine residues are replaced with alanine, the peptide is no longer active as a chemoattractant.
T6 668-728 Sentence denotes These findings are replicated by the murine ortholog Defb14.
T6 668-728 Sentence denotes These findings are replicated by the murine ortholog Defb14.
T7 729-895 Sentence denotes We restore the chemoattractant activity of Defb14 and HBD3 by introduction of a single cysteine in the fifth position (Cys V) of the beta-defensin six cysteine motif.
T7 729-895 Sentence denotes We restore the chemoattractant activity of Defb14 and HBD3 by introduction of a single cysteine in the fifth position (Cys V) of the beta-defensin six cysteine motif.
T8 896-984 Sentence denotes In contrast, a peptide with a single cysteine at the first position (Cys I) is inactive.
T8 896-984 Sentence denotes In contrast, a peptide with a single cysteine at the first position (Cys I) is inactive.
T9 985-1190 Sentence denotes Moreover, a range of overlapping linear fragments of Defb14 do not act as chemoattractants, suggesting that the chemotactic activity of this peptide is not dependent solely on an epitope surrounding Cys V.
T9 985-1190 Sentence denotes Moreover, a range of overlapping linear fragments of Defb14 do not act as chemoattractants, suggesting that the chemotactic activity of this peptide is not dependent solely on an epitope surrounding Cys V.
T10 1191-1333 Sentence denotes Full-length peptides either with alkylated cysteine residues or with cysteine residues replaced with alanine are still strongly antimicrobial.
T10 1191-1333 Sentence denotes Full-length peptides either with alkylated cysteine residues or with cysteine residues replaced with alanine are still strongly antimicrobial.
T11 1334-1490 Sentence denotes Defb14 peptide fragments were also tested for antimicrobial activity, and peptides derived from the N-terminal region display potent antimicrobial activity.
T11 1334-1490 Sentence denotes Defb14 peptide fragments were also tested for antimicrobial activity, and peptides derived from the N-terminal region display potent antimicrobial activity.
T12 1491-1660 Sentence denotes Thus, the chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds.
T12 1491-1660 Sentence denotes Thus, the chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds.
T13 1661-1783 Sentence denotes These findings are important for further understanding of the mechanism of action of defensins and for therapeutic design.
T13 1661-1783 Sentence denotes These findings are important for further understanding of the mechanism of action of defensins and for therapeutic design.