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PubMed:18180292 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.
T1 0-89 Sentence denotes c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.
T2 90-219 Sentence denotes The molecular mechanisms by which the AP-1 transcription factor c-Jun exerts its biological functions are not clearly understood.
T2 90-219 Sentence denotes The molecular mechanisms by which the AP-1 transcription factor c-Jun exerts its biological functions are not clearly understood.
T3 220-419 Sentence denotes In addition to its well established role in transcriptional regulation of gene expression, several reports have suggested that c-Jun may also regulate cell behavior by non-transcriptional mechanisms.
T3 220-419 Sentence denotes In addition to its well established role in transcriptional regulation of gene expression, several reports have suggested that c-Jun may also regulate cell behavior by non-transcriptional mechanisms.
T4 420-569 Sentence denotes Here, we report that small interfering RNA-mediated depletion of c-Jun from mammalian cells results in inhibition of 28 S and 18 S rRNA accumulation.
T4 420-569 Sentence denotes Here, we report that small interfering RNA-mediated depletion of c-Jun from mammalian cells results in inhibition of 28 S and 18 S rRNA accumulation.
T5 570-734 Sentence denotes Moreover, we show that c-Jun depletion results in partial translocation of RNA helicase DDX21, implicated in rRNA processing, from the nucleolus to the nucleoplasm.
T5 570-734 Sentence denotes Moreover, we show that c-Jun depletion results in partial translocation of RNA helicase DDX21, implicated in rRNA processing, from the nucleolus to the nucleoplasm.
T6 735-872 Sentence denotes We demonstrate that DDX21 translocation is rescued by exogenous c-Jun expression and that c-Jun depletion inhibits rRNA binding of DDX21.
T6 735-872 Sentence denotes We demonstrate that DDX21 translocation is rescued by exogenous c-Jun expression and that c-Jun depletion inhibits rRNA binding of DDX21.
T7 873-975 Sentence denotes Furthermore, the direct interaction between c-Jun and DDX21 regulates nucleolar localization of DDX21.
T7 873-975 Sentence denotes Furthermore, the direct interaction between c-Jun and DDX21 regulates nucleolar localization of DDX21.
T8 976-1155 Sentence denotes These results demonstrate that in addition to its transcriptional effects, c-Jun regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21.
T8 976-1155 Sentence denotes These results demonstrate that in addition to its transcriptional effects, c-Jun regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21.
T9 1156-1255 Sentence denotes Thus, our results demonstrate a nucleolar mechanism through which c-Jun can regulate cell behavior.
T9 1156-1255 Sentence denotes Thus, our results demonstrate a nucleolar mechanism through which c-Jun can regulate cell behavior.
T10 1256-1437 Sentence denotes Moreover, these results suggest that the phenotypes observed previously in c-Jun-depleted mouse models and cell lines could be partly due to the effects of c-Jun on rRNA processing.
T10 1256-1437 Sentence denotes Moreover, these results suggest that the phenotypes observed previously in c-Jun-depleted mouse models and cell lines could be partly due to the effects of c-Jun on rRNA processing.