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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-99 Sentence denotes 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
T1 0-99 Sentence denotes 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
TextSentencer_T2 100-111 Sentence denotes BACKGROUND:
T2 100-111 Sentence denotes BACKGROUND:
TextSentencer_T3 112-251 Sentence denotes We determined previously that hypoxia results in increased 15-lipoxygenase type 2 (15-LOX-2) expression and CXCL8 secretion in macrophages.
T3 112-251 Sentence denotes We determined previously that hypoxia results in increased 15-lipoxygenase type 2 (15-LOX-2) expression and CXCL8 secretion in macrophages.
TextSentencer_T4 252-451 Sentence denotes This study sought to determine whether 15-LOX-2 expression links directly with the secretion of inflammatory molecules in macrophages and also investigated its subsequent effects on T cell migration.
T4 252-451 Sentence denotes This study sought to determine whether 15-LOX-2 expression links directly with the secretion of inflammatory molecules in macrophages and also investigated its subsequent effects on T cell migration.
TextSentencer_T5 452-460 Sentence denotes METHODS:
T5 452-460 Sentence denotes METHODS:
TextSentencer_T6 461-550 Sentence denotes Adenovirus-mediated gene delivery caused overexpression of 15-LOX-2 in human macrophages.
T6 461-550 Sentence denotes Adenovirus-mediated gene delivery caused overexpression of 15-LOX-2 in human macrophages.
TextSentencer_T7 551-684 Sentence denotes We used cytometric bead array to measure chemokine secretion, and assessed T cell migration by counting cells in chemotaxis chambers.
T7 551-684 Sentence denotes We used cytometric bead array to measure chemokine secretion, and assessed T cell migration by counting cells in chemotaxis chambers.
TextSentencer_T8 685-751 Sentence denotes Expression of chemokine receptors was determined by FACS analysis.
T8 685-751 Sentence denotes Expression of chemokine receptors was determined by FACS analysis.
TextSentencer_T9 752-817 Sentence denotes Using siRNA, we reduced 15-LOX-2 expression in human macrophages.
T9 752-817 Sentence denotes Using siRNA, we reduced 15-LOX-2 expression in human macrophages.
TextSentencer_T10 818-853 Sentence denotes We used scrambled siRNA as control.
T10 818-853 Sentence denotes We used scrambled siRNA as control.
TextSentencer_T11 854-862 Sentence denotes RESULTS:
T11 854-862 Sentence denotes RESULTS:
TextSentencer_T12 863-969 Sentence denotes Macrophages that overexpress 15-LOX-2 showed increased secretion of chemokine CXCL10 after 24h incubation.
T12 863-969 Sentence denotes Macrophages that overexpress 15-LOX-2 showed increased secretion of chemokine CXCL10 after 24h incubation.
TextSentencer_T13 970-1120 Sentence denotes In addition, preconditioned medium from 15-LOX-2-overexpressing cells increased T cell migration and surface expression of CXCR3, the CXCL10 receptor.
T13 970-1120 Sentence denotes In addition, preconditioned medium from 15-LOX-2-overexpressing cells increased T cell migration and surface expression of CXCR3, the CXCL10 receptor.
TextSentencer_T14 1121-1240 Sentence denotes Knockdown of 15-LOX-2 expression decreased CXCL10 secretion from hypoxic macrophages and also reduced T cell migration.
T14 1121-1240 Sentence denotes Knockdown of 15-LOX-2 expression decreased CXCL10 secretion from hypoxic macrophages and also reduced T cell migration.
TextSentencer_T15 1241-1252 Sentence denotes CONCLUSION:
T15 1241-1252 Sentence denotes CONCLUSION:
TextSentencer_T16 1253-1346 Sentence denotes In macrophages, overexpression of 15-LOX-2 results in increased secretion of CXCL10 and CCL2.
T16 1253-1346 Sentence denotes In macrophages, overexpression of 15-LOX-2 results in increased secretion of CXCL10 and CCL2.
TextSentencer_T17 1347-1515 Sentence denotes Products released in response to increased 15-LOX-2 activation lead to increased expression of CD69, the T cell activation marker as well as increased T cell migration.
T17 1347-1515 Sentence denotes Products released in response to increased 15-LOX-2 activation lead to increased expression of CD69, the T cell activation marker as well as increased T cell migration.
TextSentencer_T18 1516-1653 Sentence denotes Therefore, increased expression of 15-LOX-2 induced by hypoxia may participate in T cell recruitment in diseases such as atherosclerosis.
T18 1516-1653 Sentence denotes Therefore, increased expression of 15-LOX-2 induced by hypoxia may participate in T cell recruitment in diseases such as atherosclerosis.