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PubMed:18046082 JSONTXT 34 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-126 Sentence denotes Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy.
T1 0-126 Sentence denotes Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy.
TextSentencer_T2 127-143 Sentence denotes BACKGROUND/AIMS:
T2 127-143 Sentence denotes BACKGROUND/AIMS:
TextSentencer_T3 144-334 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by thrombus-like substances in markedly dilated glomerular capillaries and elevated plasma levels of apolipoprotein E (apoE).
T3 144-334 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by thrombus-like substances in markedly dilated glomerular capillaries and elevated plasma levels of apolipoprotein E (apoE).
TextSentencer_T4 335-506 Sentence denotes Previous studies have shown that genetic disorders of apoE may contribute to the pathogenesis of LPG, but LPG may not be caused by apoE gene mutations in Chinese patients.
T4 335-506 Sentence denotes Previous studies have shown that genetic disorders of apoE may contribute to the pathogenesis of LPG, but LPG may not be caused by apoE gene mutations in Chinese patients.
TextSentencer_T5 507-601 Sentence denotes This study investigated the association of a new variant of apoE with LPG in a Chinese family.
T5 507-601 Sentence denotes This study investigated the association of a new variant of apoE with LPG in a Chinese family.
TextSentencer_T6 602-610 Sentence denotes METHODS:
T6 602-610 Sentence denotes METHODS:
TextSentencer_T7 611-671 Sentence denotes The apoE gene in a family with 4 LPG patients was sequenced.
T7 611-671 Sentence denotes The apoE gene in a family with 4 LPG patients was sequenced.
TextSentencer_T8 672-793 Sentence denotes The polymerase chain reaction product of coding region of apoE exon 4 was cloned into pMD 18-T vector and then sequenced.
T8 672-793 Sentence denotes The polymerase chain reaction product of coding region of apoE exon 4 was cloned into pMD 18-T vector and then sequenced.
TextSentencer_T9 794-802 Sentence denotes RESULTS:
T9 794-802 Sentence denotes RESULTS:
TextSentencer_T10 803-923 Sentence denotes A novel point mutation in exon 4 of the apoE gene was identified in all 4 LPG patients and 1 asymptomatic family member.
T10 803-923 Sentence denotes A novel point mutation in exon 4 of the apoE gene was identified in all 4 LPG patients and 1 asymptomatic family member.
TextSentencer_T11 924-1076 Sentence denotes Sequence analysis confirmed a nucleotide G to C point mutation in exon 4 (base 308) of the apoE gene in all patients and the asymptomatic family member.
T11 924-1076 Sentence denotes Sequence analysis confirmed a nucleotide G to C point mutation in exon 4 (base 308) of the apoE gene in all patients and the asymptomatic family member.
TextSentencer_T12 1077-1200 Sentence denotes This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 150 of apoE.
T12 1077-1200 Sentence denotes This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 150 of apoE.
TextSentencer_T13 1201-1259 Sentence denotes Those patients were all heterozygotes with apoE Guangzhou.
T13 1201-1259 Sentence denotes Those patients were all heterozygotes with apoE Guangzhou.
TextSentencer_T14 1260-1362 Sentence denotes One of 2 grandsons was a heterozygous carrier of apoE Guangzhou, although he did not have proteinuria.
T14 1260-1362 Sentence denotes One of 2 grandsons was a heterozygous carrier of apoE Guangzhou, although he did not have proteinuria.
TextSentencer_T15 1363-1374 Sentence denotes CONCLUSION:
T15 1363-1374 Sentence denotes CONCLUSION:
TextSentencer_T16 1375-1500 Sentence denotes The results of this study suggest that apoE (arginine 150 proline) is a novel apoE variant that etiologically related to LPG.
T16 1375-1500 Sentence denotes The results of this study suggest that apoE (arginine 150 proline) is a novel apoE variant that etiologically related to LPG.
TextSentencer_T17 1501-1640 Sentence denotes This variant (apoE Guangzhou) may cause a marked molecular conformational change of the apoE and thus impair its binding ability to lipids.
T17 1501-1640 Sentence denotes This variant (apoE Guangzhou) may cause a marked molecular conformational change of the apoE and thus impair its binding ability to lipids.