> top > projects > sentences > docs > PubMed:17923481 > annotations
sentences Home  

PubMed:17923481 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-121 Sentence denotes Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.
T1 0-121 Sentence denotes Pyruvate dehydrogenase complex deficiency caused by ubiquitination and proteasome-mediated degradation of the E1 subunit.
TextSentencer_T2 122-283 Sentence denotes Congenital deficiencies of the human pyruvate dehydrogenase (PDH) complex are considered to be due to loss of function mutations in one of the component enzymes.
T2 122-283 Sentence denotes Congenital deficiencies of the human pyruvate dehydrogenase (PDH) complex are considered to be due to loss of function mutations in one of the component enzymes.
TextSentencer_T3 284-377 Sentence denotes Here we describe a case of PDH deficiency associated with the PDH E1beta subunit (PDHB) gene.
T3 284-377 Sentence denotes Here we describe a case of PDH deficiency associated with the PDH E1beta subunit (PDHB) gene.
TextSentencer_T4 378-469 Sentence denotes The clinical phenotype of the patient was consistent with reported cases of PDH deficiency.
T4 378-469 Sentence denotes The clinical phenotype of the patient was consistent with reported cases of PDH deficiency.
TextSentencer_T5 470-630 Sentence denotes Cultured skin fibroblasts demonstrated a 55% reduction in PDH activity and markedly decreased immunoreactivity for PDHB protein, compared with healthy controls.
T5 470-630 Sentence denotes Cultured skin fibroblasts demonstrated a 55% reduction in PDH activity and markedly decreased immunoreactivity for PDHB protein, compared with healthy controls.
TextSentencer_T6 631-782 Sentence denotes Surprisingly, nucleotide sequence analyses of cDNAs corresponding to the patient PDH E1alpha (PDHA1) and PDHB genes revealed no pathological mutations.
T6 631-782 Sentence denotes Surprisingly, nucleotide sequence analyses of cDNAs corresponding to the patient PDH E1alpha (PDHA1) and PDHB genes revealed no pathological mutations.
TextSentencer_T7 783-912 Sentence denotes Moreover, the relative expression level of PDHB mRNA and the rates of transcription and translation of the PDHB gene were normal.
T7 783-912 Sentence denotes Moreover, the relative expression level of PDHB mRNA and the rates of transcription and translation of the PDHB gene were normal.
TextSentencer_T8 913-1114 Sentence denotes However, PDC activity could be restored in cells from this patient following treatment with MG132, a specific proteasome inhibitor, and normal levels of E1beta could be detected in MG132-treated cells.
T8 913-1114 Sentence denotes However, PDC activity could be restored in cells from this patient following treatment with MG132, a specific proteasome inhibitor, and normal levels of E1beta could be detected in MG132-treated cells.
TextSentencer_T9 1115-1408 Sentence denotes Similar results were obtained following treatment with Tyr-phostin 23 (Tyr23), a specific inhibitor of epidermal growth factor receptor-protein-tyrosine kinase (EGFR-PTK), which also restored E1beta protein levels to those in cells from healthy subjects or from patients with PDHA1 deficiency.
T9 1115-1408 Sentence denotes Similar results were obtained following treatment with Tyr-phostin 23 (Tyr23), a specific inhibitor of epidermal growth factor receptor-protein-tyrosine kinase (EGFR-PTK), which also restored E1beta protein levels to those in cells from healthy subjects or from patients with PDHA1 deficiency.
TextSentencer_T10 1409-1684 Sentence denotes The index patient's cells contained a high basal level of EGFR-PTK activity that correlated with the high level of ubiquitination of cellular proteins, although the total EGFR protein levels were similar to those in cells from Elalpha-deficient subjects and healthy subjects.
T10 1409-1684 Sentence denotes The index patient's cells contained a high basal level of EGFR-PTK activity that correlated with the high level of ubiquitination of cellular proteins, although the total EGFR protein levels were similar to those in cells from Elalpha-deficient subjects and healthy subjects.
TextSentencer_T11 1685-1934 Sentence denotes These data indicate that PDH deficiency in our patient involves a post-translational modification in which EGFR-PTK-mediated tyrosine phosphorylation of the E1beta protein leads to enhanced ubiquitination followed by proteasome-mediated degradation.
T11 1685-1934 Sentence denotes These data indicate that PDH deficiency in our patient involves a post-translational modification in which EGFR-PTK-mediated tyrosine phosphorylation of the E1beta protein leads to enhanced ubiquitination followed by proteasome-mediated degradation.
TextSentencer_T12 1935-2073 Sentence denotes They also provide a novel mechanism accounting for congenital deficiency of the PDH complex and perhaps other inborn errors of metabolism.
T12 1935-2073 Sentence denotes They also provide a novel mechanism accounting for congenital deficiency of the PDH complex and perhaps other inborn errors of metabolism.