| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-172 |
Sentence |
denotes |
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. |
| T2 |
173-351 |
Sentence |
denotes |
Type I interferon gene induction relies on IKK-related kinase TBK1 and IKKepsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. |
| T3 |
352-436 |
Sentence |
denotes |
The scaffold proteins that assemble these kinase complexes are poorly characterized. |
| T4 |
437-633 |
Sentence |
denotes |
We show here that TANK/ITRAF is required for the TBK1- and IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex. |
| T5 |
634-737 |
Sentence |
denotes |
Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation. |
| T6 |
738-1012 |
Sentence |
denotes |
Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity. |
| T7 |
1013-1369 |
Sentence |
denotes |
Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKKepsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys(63)-linked polyubiquitination of their scaffold protein, TANK. |
