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PubMed:17701343 JSONTXT 41 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-154 Sentence denotes Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies.
T1 0-154 Sentence denotes Synthetic sulfogalactosylceramide (sulfatide) and its use for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies.
TextSentencer_T2 155-326 Sentence denotes 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A.
T2 155-326 Sentence denotes 3-O-Sulfogalactosylceramides (sulfatides) accumulate in the genetic disease metachromatic leukodystrophy which is due to a defect in the catabolic enzyme, arylsulfatase A.
TextSentencer_T3 327-428 Sentence denotes Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity.
T3 327-428 Sentence denotes Clinical diagnosis is usually confirmed by in vitro enzymatic deficiency of arylsulfatase A activity.
TextSentencer_T4 429-571 Sentence denotes The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency.
T4 429-571 Sentence denotes The diagnosis may be complicated because of arylsulfatase A pseudo-deficiencies and another cause of MLD, sphingolipid activator B deficiency.
TextSentencer_T5 572-698 Sentence denotes As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test.
T5 572-698 Sentence denotes As large quantities of sulfatides can be found in the urine in this disease, sulfatiduria appears as an extremely useful test.
TextSentencer_T6 699-846 Sentence denotes As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up.
T6 699-846 Sentence denotes As recently enzyme replacement is underway, the quantitative determination, using an internal standard, appears particularly useful as a follow-up.
TextSentencer_T7 847-1037 Sentence denotes Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-beta-D-C17 galactosylceramide (3-O-Sulfo-D: -Galactosyl-beta1'-->1-N-Heptadecanoyl-D-erythro-Sphingosine).
T7 847-1037 Sentence denotes Thus a non-physiological sulfatide was synthesized for this purpose, i.e. 3-O-sulfo-beta-D-C17 galactosylceramide (3-O-Sulfo-D: -Galactosyl-beta1'-->1-N-Heptadecanoyl-D-erythro-Sphingosine).
TextSentencer_T8 1038-1170 Sentence denotes It has been prepared through condensation of an azidosphingosine derivative with a protected D-galactopyranosyltrichloroacetimidate.
T8 1038-1170 Sentence denotes It has been prepared through condensation of an azidosphingosine derivative with a protected D-galactopyranosyltrichloroacetimidate.
TextSentencer_T9 1171-1241 Sentence denotes Reduction of the azide was followed by acylation of a C-17 fatty acid.
T9 1171-1241 Sentence denotes Reduction of the azide was followed by acylation of a C-17 fatty acid.
TextSentencer_T10 1242-1453 Sentence denotes The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3'-sulfated beta-galactosyl C-17 ceramide.
T10 1242-1453 Sentence denotes The key step was achieved by selective sulfation of the desired hydroxyl group on the sugar residue of the galactosylceramide using the stannylene methodology to give a 3'-sulfated beta-galactosyl C-17 ceramide.