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PubMed:1761570 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency.
T1 0-133 Sentence denotes Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency.
T2 134-252 Sentence denotes A donor splice site mutation was found in the lipoprotein lipase (LPL) gene of a patient with familial LPL deficiency.
T2 134-252 Sentence denotes A donor splice site mutation was found in the lipoprotein lipase (LPL) gene of a patient with familial LPL deficiency.
T3 253-335 Sentence denotes The mutation, a G----A substitution, occurred at the first nucleotide of intron 2.
T3 253-335 Sentence denotes The mutation, a G----A substitution, occurred at the first nucleotide of intron 2.
T4 336-440 Sentence denotes Northern blot analysis of total RNA from the patient showed strikingly low levels of LPL-specific mRNAs.
T4 336-440 Sentence denotes Northern blot analysis of total RNA from the patient showed strikingly low levels of LPL-specific mRNAs.
T5 441-523 Sentence denotes Using the polymerase chain reaction, the LPL mRNA splicing was analyzed in detail.
T5 441-523 Sentence denotes Using the polymerase chain reaction, the LPL mRNA splicing was analyzed in detail.
T6 524-710 Sentence denotes The results demonstrated that no normal splicing occurred at the authentic splice site; rather a cryptic splice site 18 bases upstream from the mutation site was preferentially utilized.
T6 524-710 Sentence denotes The results demonstrated that no normal splicing occurred at the authentic splice site; rather a cryptic splice site 18 bases upstream from the mutation site was preferentially utilized.
T7 711-864 Sentence denotes Although the resulting alteration in mRNA was a minute in-frame 18-base deletion, the amount of the abnormal transcript was only 1/12 that of the normal.
T7 711-864 Sentence denotes Although the resulting alteration in mRNA was a minute in-frame 18-base deletion, the amount of the abnormal transcript was only 1/12 that of the normal.
T8 865-1004 Sentence denotes In addition to this major cryptic splice site, we also identified multiple minor sites which were utilized at extremely lower efficiencies.
T8 865-1004 Sentence denotes In addition to this major cryptic splice site, we also identified multiple minor sites which were utilized at extremely lower efficiencies.
T9 1005-1141 Sentence denotes Unexpectedly, one of these minor sites was also used as an alternative splice site in the normal subject at a comparably low efficiency.
T9 1005-1141 Sentence denotes Unexpectedly, one of these minor sites was also used as an alternative splice site in the normal subject at a comparably low efficiency.
T10 1142-1395 Sentence denotes The sequences of these minor cryptic sites possessed many of the characteristics common to those of other normal splice sites, indicating that even such minor sites should have also been selected according to the general rules for splice site selection.
T10 1142-1395 Sentence denotes The sequences of these minor cryptic sites possessed many of the characteristics common to those of other normal splice sites, indicating that even such minor sites should have also been selected according to the general rules for splice site selection.
T11 1396-1542 Sentence denotes These results demonstrate that upon mutation, a broad spectrum of cryptic splice sites is activated in vivo at the sites' respective efficiencies.
T11 1396-1542 Sentence denotes These results demonstrate that upon mutation, a broad spectrum of cryptic splice sites is activated in vivo at the sites' respective efficiencies.